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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1996 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1996 Volume 9 Issue 5

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Article

Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma

  • Authors:
    • K Mimori
    • M Mori
    • K Mafune
    • Y Tanaka
    • J Li
    • Y Fukumaki
    • M Matsuda
    • K Sugimachi
    • T Akiyoshi

  • View Affiliations / Copyright

    Affiliations: KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. SAITAMA CANC CTR,DEPT SURG,INA,SAITAMA,JAPAN. KYUSHU UNIV,DEPT SURG 2,FUKUOKA 812,JAPAN. KYUSHU UNIV,DEPT GENET INFORMAT,FUKUOKA 812,JAPAN.
  • Pages: 907-910
    |
    Published online on: November 1, 1996
       https://doi.org/10.3892/ijo.9.5.907
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Abstract

Alpha-1-antitrypsin (alpha 1AT) is present not only in the normal gastrointestine, but in malignant gastrointestinal tissue as well. We studied the expression of alpha 1AT mRNA in 30 cases of esophageal carcinoma using a Northern blot analysis. In addition, we also examined the expression of matrix metalloproteinase 7 (MMP7) mRNA in the latest 15 cases by reverse transcriptase-polymerase chain reaction (RT-PCR) method to clarify the relationship between the alpha 1AT and MMP7. In 25 of the 30, the expression of alpha 1AT mRNA in esophageal carcinomatous tissue (T) was lower than that in the corresponding normal tissue (N) of the esophagus. The T/N ratio of alpha 1AT mRNA expression showed a significant inverse correlation with the depth of tumor invasion, lymph node metastasis and stage of disease (p=0.042, p=0.0001 and p=0.002, respectively). The T/N ratio of alpha 1AT bad a converse correlation with that of MMP7 (p=0.034). The current study thus suggested that i) the lower expression of T/N expression may be a marker for the biological aggressiveness of esophageal carcinoma, and ii) the reduction of alpha 1AT may be partially correlated with the overexpression of MMP7 in tumor tissue.

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Copy and paste a formatted citation
Spandidos Publications style
Mimori K, Mori M, Mafune K, Tanaka Y, Li J, Fukumaki Y, Matsuda M, Sugimachi K and Akiyoshi T: Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma. Int J Oncol 9: 907-910, 1996.
APA
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y. ... Akiyoshi, T. (1996). Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma. International Journal of Oncology, 9, 907-910. https://doi.org/10.3892/ijo.9.5.907
MLA
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y., Matsuda, M., Sugimachi, K., Akiyoshi, T."Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma". International Journal of Oncology 9.5 (1996): 907-910.
Chicago
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y., Matsuda, M., Sugimachi, K., Akiyoshi, T."Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma". International Journal of Oncology 9, no. 5 (1996): 907-910. https://doi.org/10.3892/ijo.9.5.907
Copy and paste a formatted citation
x
Spandidos Publications style
Mimori K, Mori M, Mafune K, Tanaka Y, Li J, Fukumaki Y, Matsuda M, Sugimachi K and Akiyoshi T: Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma. Int J Oncol 9: 907-910, 1996.
APA
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y. ... Akiyoshi, T. (1996). Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma. International Journal of Oncology, 9, 907-910. https://doi.org/10.3892/ijo.9.5.907
MLA
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y., Matsuda, M., Sugimachi, K., Akiyoshi, T."Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma". International Journal of Oncology 9.5 (1996): 907-910.
Chicago
Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y., Matsuda, M., Sugimachi, K., Akiyoshi, T."Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma". International Journal of Oncology 9, no. 5 (1996): 907-910. https://doi.org/10.3892/ijo.9.5.907
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