Antiapoptotic activity of bovine papilloma virus

  • Authors:
    • W Melchinger
    • S Strauss
    • B Zucker
    • G Bauer
  • View Affiliations

  • Published online on: November 1, 1996     https://doi.org/10.3892/ijo.9.5.927
  • Pages: 927-933
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Abstract

Transformed fibroblasts have been recently shown to be sensitive for induction of apoptosis by TGF-beta-treated neighbouring untransformed cells. Cells transformed by a variety of different transformation principles were regularly sensitive for intercellular induction of apoptosis, but fibroblasts transformed by bovine papillomavirus (BPV) represented a striking exception. In contrast to chemically transformed C127 cells, BPV-transformed C127 cells showed resistance against intercellular induction of apoptosis. In addition, BPV-transformed cells were resistant against induction of apoptosis by ROS in glutathione depleted cells. The antiapoptotic function of papillomaviruses may be of central importance for papillomavirus-induced tumor formation as it can protect transformed cells from intercellular control of oncogenesis.

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November 1996
Volume 9 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Melchinger W, Strauss S, Zucker B and Bauer G: Antiapoptotic activity of bovine papilloma virus. Int J Oncol 9: 927-933, 1996
APA
Melchinger, W., Strauss, S., Zucker, B., & Bauer, G. (1996). Antiapoptotic activity of bovine papilloma virus. International Journal of Oncology, 9, 927-933. https://doi.org/10.3892/ijo.9.5.927
MLA
Melchinger, W., Strauss, S., Zucker, B., Bauer, G."Antiapoptotic activity of bovine papilloma virus". International Journal of Oncology 9.5 (1996): 927-933.
Chicago
Melchinger, W., Strauss, S., Zucker, B., Bauer, G."Antiapoptotic activity of bovine papilloma virus". International Journal of Oncology 9, no. 5 (1996): 927-933. https://doi.org/10.3892/ijo.9.5.927