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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2008 Volume 33 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 33 Issue 3

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Article Open Access

Tumor hypoxia: Impact on gene amplification in glioblastoma

  • Authors:
    • Ulrike Fischer
    • Jens Radermacher
    • Jens Mayer
    • Yasmin Mehraein
    • Eckart Meese

  • View Affiliations / Copyright

    Affiliations: Institut für Humangenetik, Universitätskliniken des Saarlandes, D-66421 Homburg/Saar, Germany. hgufis@uniklinikum-saarland.de
  • Pages: 509-515
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/ijo_00000034
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Abstract

Gene amplification is frequently found in human glioblastoma but the mechanisms driving amplifications remain to be elucidated. Hypoxia as hallmark of glioblastoma is known to be involved in the induction of fragile sites that are central to gene amplification. We analyzed the potential of hypoxia (pO2 0%) and mini hypoxia (pO2 5%) to induce fragile sites within a homogeneously staining region (HSR) at 12q14-15 in a glioblastoma cell line (TX3868). Treatment of cells by hypoxia or by mini hypoxia induced double minutes (DMs) and caused breakage of the HSR structure at 12q14-15, suggesting a novel hypoxia inducible fragile site on 12q. Treatment with aphidicolin, a known fragile site inducer, indicates that the hypoxia inducible fragile site is a common fragile site. Reintegration of amplified sequences and occurrence of anaphase-bridge-like structures shows that mini hypoxia and hypoxia are able to initiate amplification processes in human glioblastoma cells. Hypoxia as known tumor microenvironment factor is crucial for the development of amplifications in glioblastoma. The identification and characterization of novel common fragile sites induced by hypoxia will improve the understanding of mechanisms underlying amplifications in glioblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Fischer U, Radermacher J, Mayer J, Mehraein Y and Meese E: Tumor hypoxia: Impact on gene amplification in glioblastoma. Int J Oncol 33: 509-515, 2008.
APA
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., & Meese, E. (2008). Tumor hypoxia: Impact on gene amplification in glioblastoma. International Journal of Oncology, 33, 509-515. https://doi.org/10.3892/ijo_00000034
MLA
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., Meese, E."Tumor hypoxia: Impact on gene amplification in glioblastoma". International Journal of Oncology 33.3 (2008): 509-515.
Chicago
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., Meese, E."Tumor hypoxia: Impact on gene amplification in glioblastoma". International Journal of Oncology 33, no. 3 (2008): 509-515. https://doi.org/10.3892/ijo_00000034
Copy and paste a formatted citation
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Spandidos Publications style
Fischer U, Radermacher J, Mayer J, Mehraein Y and Meese E: Tumor hypoxia: Impact on gene amplification in glioblastoma. Int J Oncol 33: 509-515, 2008.
APA
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., & Meese, E. (2008). Tumor hypoxia: Impact on gene amplification in glioblastoma. International Journal of Oncology, 33, 509-515. https://doi.org/10.3892/ijo_00000034
MLA
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., Meese, E."Tumor hypoxia: Impact on gene amplification in glioblastoma". International Journal of Oncology 33.3 (2008): 509-515.
Chicago
Fischer, U., Radermacher, J., Mayer, J., Mehraein, Y., Meese, E."Tumor hypoxia: Impact on gene amplification in glioblastoma". International Journal of Oncology 33, no. 3 (2008): 509-515. https://doi.org/10.3892/ijo_00000034
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