PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma

  • Authors:
    • L. Longo
    • S. Borghini
    • F. Schena
    • S. Parodi
    • D. Albino
    • T. Bachetti
    • L. Da Prato
    • M. Truini
    • C. Gambini
    • G. P. Tonini
    • I. Ceccherini
    • P. Perri
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/ijo_00000086
  • Pages: 985-991
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Abstract

The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination. In this light, we have carried out a quantitative expression analysis of PHOX2B and its paralogue PHOX2A on a panel of NB cell lines and NB tumour samples to identify a possible differential expression between NB cells and their normal counterpart (adrenal medulla cells). Our results revealed that both PHOX2A and PHOX2B are over-expressed in tumour samples and NB cell lines. Particularly, the expression levels of the two genes in NB cell lines show a highly significant correlation, suggesting their possible synergistic role or a coordinated expression regulation. Furthermore, PHOX2 gene over-expression in NB tumours and cell lines suggests these genes may be widely involved in NB development through either a direct mechanism of up-regulation or a failure in maintaining proper transcript levels after embryonic development.

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November 2008
Volume 33 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Longo L, Borghini S, Schena F, Parodi S, Albino D, Bachetti T, Da Prato L, Truini M, Gambini C, Tonini GP, Tonini GP, et al: PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. Int J Oncol 33: 985-991, 2008
APA
Longo, L., Borghini, S., Schena, F., Parodi, S., Albino, D., Bachetti, T. ... Perri, P. (2008). PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. International Journal of Oncology, 33, 985-991. https://doi.org/10.3892/ijo_00000086
MLA
Longo, L., Borghini, S., Schena, F., Parodi, S., Albino, D., Bachetti, T., Da Prato, L., Truini, M., Gambini, C., Tonini, G. P., Ceccherini, I., Perri, P."PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma". International Journal of Oncology 33.5 (2008): 985-991.
Chicago
Longo, L., Borghini, S., Schena, F., Parodi, S., Albino, D., Bachetti, T., Da Prato, L., Truini, M., Gambini, C., Tonini, G. P., Ceccherini, I., Perri, P."PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma". International Journal of Oncology 33, no. 5 (2008): 985-991. https://doi.org/10.3892/ijo_00000086