Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck

  • Authors:
    • Yusuke Zushi
    • Kazuma Noguchi
    • Susumu Hashitani
    • Kazunari Sakurai
    • Emi Segawa
    • Kazuki Takaoka
    • Yukiyo Toyohara
    • Noriaki Tanaka
    • Hiromitsu Kishimoto
    • Masahiro Urade
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/ijo_00000102
  • Pages: 1133-1139
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Abstract

Adenoid cystic carcinoma (ACC) may acquire a chemokine-mediated mechanism during the process of metastasis. To investigate the involvement of chemokines in metastasis from ACC, expression of CXCR4 in surgical specimens of ACC and two tumor lines transplantable to nude mice was examined immunohistochemically. In addition, the expression levels of CXCR4 protein and mRNA were examined by Western blotting and reverse-transcription polymerase chain reaction. Our results showed that patients whose tumors expressed high levels of CXCR4 had metastases to the regional lymph nodes and the lung, resulting in poor outcomes. ACCs showing a solid or cribriform pattern with distant metastasis were strongly positive for CXCR4, while those showing a tubular or cribriform pattern without metastasis were weakly positive for CXCR4. In the in vivo model, ACCY tumor showed increasing expression levels of CXCR4 with tumor growth, and the histological pattern changed from cribriform to solid. The histological pattern of ACCI, associated with spontaneous metastasis to the neck, changed from cribriform to undifferentiated carcinoma and was highly metastatic to the lung. This tumor showed high levels of CXCR4 protein and mRNA. These results suggest that CXCR4 expression, histological patterns, and metastatic potential are closely related in ACC.

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December 2008
Volume 33 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zushi Y, Noguchi K, Hashitani S, Sakurai K, Segawa E, Takaoka K, Toyohara Y, Tanaka N, Kishimoto H, Urade M, Urade M, et al: Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck. Int J Oncol 33: 1133-1139, 2008
APA
Zushi, Y., Noguchi, K., Hashitani, S., Sakurai, K., Segawa, E., Takaoka, K. ... Urade, M. (2008). Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck. International Journal of Oncology, 33, 1133-1139. https://doi.org/10.3892/ijo_00000102
MLA
Zushi, Y., Noguchi, K., Hashitani, S., Sakurai, K., Segawa, E., Takaoka, K., Toyohara, Y., Tanaka, N., Kishimoto, H., Urade, M."Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck". International Journal of Oncology 33.6 (2008): 1133-1139.
Chicago
Zushi, Y., Noguchi, K., Hashitani, S., Sakurai, K., Segawa, E., Takaoka, K., Toyohara, Y., Tanaka, N., Kishimoto, H., Urade, M."Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck". International Journal of Oncology 33, no. 6 (2008): 1133-1139. https://doi.org/10.3892/ijo_00000102