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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2008 Volume 33 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 33 Issue 6

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Article

Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma

  • Authors:
    • Hamdy Saad Mohammad
    • Kazutaka Kurokohchi
    • Hirohito Yoneyama
    • Masaaki Tokuda
    • Asahiro Morishita
    • Gong Jian
    • Liu Shi
    • Masayuki Murota
    • Joji Tani
    • Kiyohito Kato
    • Hisaaki Miyoshi
    • Akihiro Deguchi
    • Takashi Himoto
    • Hisashi Usuki
    • Hisao Wakabayashi
    • Kunihiko Izuishi
    • Yasuyuki Suzuki
    • Hisakazu Iwama
    • Kazushi Deguchi
    • Naohito Uchida
    • Eman A. Sabet
    • Usama A. Arafa
    • Ali T.A. Hassan
    • Adel A. El-Sayed
    • Tsutomu Masaki

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Neurology, Kagawa Medical University School of Medicine, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
  • Pages: 1157-1163
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/ijo_00000105
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Abstract

Annexins (ANXs) constitute a family of Ca2+-dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in various liver diseases including HCC remains obscure. In the present study, the protein and mRNA levels of ANXA2, as well as its localization, were determined for the normal human liver, chronic hepatitis liver, and non-tumorous and tumorous portions of HCC tissues. ANXA2 was rarely detected in either normal or chronic hepatitis liver tissues, whereas it was overexpressed at both the transcriptional and translational levels in tumorous and non-tumorous regions of HCC. In addition, in many cases, more ANXA2 was expressed in the tumorous portion than in the non-tumorous portion of HCC. The expression of ANXA2 was mainly localized in cancer cells, especially in poorly differentiated HCC. Furthermore, ANXA2 was tyrosine-phosphorylated in HCC. These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L, Murota M, Tani J, Kato K, Kato K, et al: Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol 33: 1157-1163, 2008.
APA
Mohammad, H.S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G. ... Masaki, T. (2008). Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. International Journal of Oncology, 33, 1157-1163. https://doi.org/10.3892/ijo_00000105
MLA
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33.6 (2008): 1157-1163.
Chicago
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33, no. 6 (2008): 1157-1163. https://doi.org/10.3892/ijo_00000105
Copy and paste a formatted citation
x
Spandidos Publications style
Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L, Murota M, Tani J, Kato K, Kato K, et al: Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol 33: 1157-1163, 2008.
APA
Mohammad, H.S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G. ... Masaki, T. (2008). Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. International Journal of Oncology, 33, 1157-1163. https://doi.org/10.3892/ijo_00000105
MLA
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33.6 (2008): 1157-1163.
Chicago
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33, no. 6 (2008): 1157-1163. https://doi.org/10.3892/ijo_00000105
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