Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma

  • Authors:
    • Hamdy Saad Mohammad
    • Kazutaka Kurokohchi
    • Hirohito Yoneyama
    • Masaaki Tokuda
    • Asahiro Morishita
    • Gong Jian
    • Liu Shi
    • Masayuki Murota
    • Joji Tani
    • Kiyohito Kato
    • Hisaaki Miyoshi
    • Akihiro Deguchi
    • Takashi Himoto
    • Hisashi Usuki
    • Hisao Wakabayashi
    • Kunihiko Izuishi
    • Yasuyuki Suzuki
    • Hisakazu Iwama
    • Kazushi Deguchi
    • Naohito Uchida
    • Eman A. Sabet
    • Usama A. Arafa
    • Ali T.A. Hassan
    • Adel A. El-Sayed
    • Tsutomu Masaki
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/ijo_00000105
  • Pages: 1157-1163
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Annexins (ANXs) constitute a family of Ca2+-dependent membrane-binding proteins; at least 20 of them have been described to date. Among these, Annexin A2 (ANXA2) has been revealed as a multi-functional protein in vitro. Its actual role in vivo, however, requires further investigation. We already reported that ANX-I (ANXA1) was up-regulated in hepatocellular carcinoma (HCC). The role of ANXA2 in various liver diseases including HCC remains obscure. In the present study, the protein and mRNA levels of ANXA2, as well as its localization, were determined for the normal human liver, chronic hepatitis liver, and non-tumorous and tumorous portions of HCC tissues. ANXA2 was rarely detected in either normal or chronic hepatitis liver tissues, whereas it was overexpressed at both the transcriptional and translational levels in tumorous and non-tumorous regions of HCC. In addition, in many cases, more ANXA2 was expressed in the tumorous portion than in the non-tumorous portion of HCC. The expression of ANXA2 was mainly localized in cancer cells, especially in poorly differentiated HCC. Furthermore, ANXA2 was tyrosine-phosphorylated in HCC. These data suggest that overexpression and tyrosine phosphorylation of ANXA2 play important roles in the malignant transformation process leading to HCC and are related to the histological grade of HCC.

Related Articles

Journal Cover

December 2008
Volume 33 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L, Murota M, Tani J, Kato K, Kato K, et al: Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol 33: 1157-1163, 2008
APA
Mohammad, H.S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G. ... Masaki, T. (2008). Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. International Journal of Oncology, 33, 1157-1163. https://doi.org/10.3892/ijo_00000105
MLA
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33.6 (2008): 1157-1163.
Chicago
Mohammad, H. S., Kurokohchi, K., Yoneyama, H., Tokuda, M., Morishita, A., Jian, G., Shi, L., Murota, M., Tani, J., Kato, K., Miyoshi, H., Deguchi, A., Himoto, T., Usuki, H., Wakabayashi, H., Izuishi, K., Suzuki, Y., Iwama, H., Deguchi, K., Uchida, N., Sabet, E. A., Arafa, U. A., Hassan, A. T., El-Sayed, A. A., Masaki, T."Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma". International Journal of Oncology 33, no. 6 (2008): 1157-1163. https://doi.org/10.3892/ijo_00000105