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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2008 Volume 33 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 33 Issue 6

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Article Open Access

Activation of Notch signaling in human colon adenocarcinoma

  • Authors:
    • Michael Reedijk
    • Silvia Odorcic
    • Hui Zhang
    • Runjan Chetty
    • Carsten Tennert
    • Brendan C. Dickson
    • Gina Lockwood
    • Steven Gallinger
    • Sean E. Egan

  • View Affiliations / Copyright

    Affiliations: Program in Developmental Biology and Stem Cell Research, The Hospital for Sick Children, MaRS East Tower, Ontario M5G 1L7, Canada
  • Pages: 1223-1229
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/ijo_00000112
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Abstract

Notch and Wnt signaling function together to regulate colonic progenitor cell division and differentiation. Studies in mice have also shown that Notch signaling is required for adenoma formation in response to elevated Wnt-pathway signaling that occurs in the APCMin mouse model of human adenomatous polyposis coli. We therefore used in situ hybridization to analyze expression of Notch ligands, receptors and fringe genes, as well as the Notch target gene, HES1, in human colorectal cancer (CRC). In a small cohort of tumors, JAGGED ligands, NOTCH1, LFNG and HES1 were expressed at levels similar to, or higher than, levels observed in the crypt. To explore the possibility that Notch signaling may play a quantitative role in human CRC we next analyzed HES1 mRNA expression in 130 tumors, each associated with outcome data. The vast majority of these tumors expressed HES1, although at varying levels. Absolute expression levels did not correlate with patient survival. These results establish that JAG ligands and NOTCH1, as well as Notch receptor activation are consistent features of human CRC and support the notion that many of these tumors, like the APCMin mouse, may respond to anti-Notch therapeutic regimes.

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Copy and paste a formatted citation
Spandidos Publications style
Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC, Lockwood G, Gallinger S and Egan SE: Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol 33: 1223-1229, 2008.
APA
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B.C. ... Egan, S.E. (2008). Activation of Notch signaling in human colon adenocarcinoma. International Journal of Oncology, 33, 1223-1229. https://doi.org/10.3892/ijo_00000112
MLA
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B. C., Lockwood, G., Gallinger, S., Egan, S. E."Activation of Notch signaling in human colon adenocarcinoma". International Journal of Oncology 33.6 (2008): 1223-1229.
Chicago
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B. C., Lockwood, G., Gallinger, S., Egan, S. E."Activation of Notch signaling in human colon adenocarcinoma". International Journal of Oncology 33, no. 6 (2008): 1223-1229. https://doi.org/10.3892/ijo_00000112
Copy and paste a formatted citation
x
Spandidos Publications style
Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC, Lockwood G, Gallinger S and Egan SE: Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol 33: 1223-1229, 2008.
APA
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B.C. ... Egan, S.E. (2008). Activation of Notch signaling in human colon adenocarcinoma. International Journal of Oncology, 33, 1223-1229. https://doi.org/10.3892/ijo_00000112
MLA
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B. C., Lockwood, G., Gallinger, S., Egan, S. E."Activation of Notch signaling in human colon adenocarcinoma". International Journal of Oncology 33.6 (2008): 1223-1229.
Chicago
Reedijk, M., Odorcic, S., Zhang, H., Chetty, R., Tennert, C., Dickson, B. C., Lockwood, G., Gallinger, S., Egan, S. E."Activation of Notch signaling in human colon adenocarcinoma". International Journal of Oncology 33, no. 6 (2008): 1223-1229. https://doi.org/10.3892/ijo_00000112
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