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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2009 Volume 34 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling

  • Authors:
    • Mariana Lagadari
    • Katja Lehmann
    • Mirjana Ziemer
    • Krisztina Truta-Feles
    • Luciana Berod
    • Marco Idzko
    • Dagmar Barz
    • Thomas Kamradt
    • Azzam A. Maghazachi
    • Johannes Norgauer

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Friedrich-Schiller University, D-07740 Jena, Germany
  • Pages: 287-294
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/ijo_00000151
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Abstract

Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery. In this study we analyzed the influence of S1P on the interaction of NK cells with tumor cells such as the human melanoma cell line Hs294T and the Burkitt's lymphoma cell line Raji. We found that S1P inhibited the cytotoxic activity of NK cells. Analysis of signal transduction pathways revealed that S1P induced common signalling pathways of chemotaxins such as Gi protein-dependent actin reorganization and activation of the phosphatidylinositol 3-kinase (PI3K) dependent signal molecules, protein kinase B (PKB/Akt) and glycogen synthase kinase-3β (GSK-3β). In contrast to most chemotaxins, S1P is also able to activate Gs-dependent signalling molecules. This signalling cascade involves increase of cAMP levels and protein kinase A (PKA) activation. Additionally, blocking the regulatory subunits of PKA I abrogated the inhibitory effect of S1P, whereas the catalytic subunits were not involved. Our data indicate that S1P may contributes to the tumor escape from NK cell-dependent immunological surveillance machinery.

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Copy and paste a formatted citation
Spandidos Publications style
Lagadari M, Lehmann K, Ziemer M, Truta-Feles K, Berod L, Idzko M, Barz D, Kamradt T, Maghazachi AA, Norgauer J, Norgauer J, et al: Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. Int J Oncol 34: 287-294, 2009.
APA
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M. ... Norgauer, J. (2009). Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. International Journal of Oncology, 34, 287-294. https://doi.org/10.3892/ijo_00000151
MLA
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M., Barz, D., Kamradt, T., Maghazachi, A. A., Norgauer, J."Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling". International Journal of Oncology 34.1 (2009): 287-294.
Chicago
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M., Barz, D., Kamradt, T., Maghazachi, A. A., Norgauer, J."Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling". International Journal of Oncology 34, no. 1 (2009): 287-294. https://doi.org/10.3892/ijo_00000151
Copy and paste a formatted citation
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Spandidos Publications style
Lagadari M, Lehmann K, Ziemer M, Truta-Feles K, Berod L, Idzko M, Barz D, Kamradt T, Maghazachi AA, Norgauer J, Norgauer J, et al: Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. Int J Oncol 34: 287-294, 2009.
APA
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M. ... Norgauer, J. (2009). Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. International Journal of Oncology, 34, 287-294. https://doi.org/10.3892/ijo_00000151
MLA
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M., Barz, D., Kamradt, T., Maghazachi, A. A., Norgauer, J."Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling". International Journal of Oncology 34.1 (2009): 287-294.
Chicago
Lagadari, M., Lehmann, K., Ziemer, M., Truta-Feles, K., Berod, L., Idzko, M., Barz, D., Kamradt, T., Maghazachi, A. A., Norgauer, J."Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling". International Journal of Oncology 34, no. 1 (2009): 287-294. https://doi.org/10.3892/ijo_00000151
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