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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2009 Volume 34 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 34 Issue 2

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Article

Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck

  • Authors:
    • Machiko Kimura
    • Yasumasa Kato
    • Daisuke Sano
    • Kyoko Fujita
    • Atsuko Sakakibara
    • Norio Kondo
    • Yasukazu Mikami
    • Mamoru Tsukuda

  • View Affiliations / Copyright

    Affiliations: Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan
  • Pages: 321-327
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/ijo_00000154
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Abstract

The ephB4-ephrinB2 system plays an important role in the interaction of tumor cells with endothelial cells (ECs). To assess the role of ephB4 in the in vivo growth of head and neck squamous cell carcinoma (HNSCC), we used ephrinB2-Fc, a fusion protein consisting of the extracellular domain of ephrin-B2 and the Fc portion of human IgG1, as the soluble ligand for ephB4. EphrinB2-Fc injection into HNSCC xenografted mice significantly suppressed xenograft growth, accompanied by a decrease in vessel cross-sectional area, but there was no change in vessel number. EphrinB2-Fc injection also induced the formation of mature blood vessels rich in α-smooth muscle actin positive pericytes in the xenograft tissue. In vitro assays revealed that ephrinB2-Fc inhibited the proliferation of human umbilical vein ECs (HUVECs) but not tumor cells. Furthermore, real-time quantitative RT-PCR showed that ephrinB2-Fc down-regulated matrix metalloproteinase-2 mRNA expression in HUVECs and vascular endothelial growth factor-A in tumor cells. These data suggest that treatment with ephrinB2-Fc, the soluble ligand of ephB4, inhibited the growth of HNSCC through vessel maturation/stabilization, preventing leakiness and endothelial sprout formation.

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Copy and paste a formatted citation
Spandidos Publications style
Kimura M, Kato Y, Sano D, Fujita K, Sakakibara A, Kondo N, Mikami Y and Tsukuda M: Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. Int J Oncol 34: 321-327, 2009.
APA
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N. ... Tsukuda, M. (2009). Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. International Journal of Oncology, 34, 321-327. https://doi.org/10.3892/ijo_00000154
MLA
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N., Mikami, Y., Tsukuda, M."Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck". International Journal of Oncology 34.2 (2009): 321-327.
Chicago
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N., Mikami, Y., Tsukuda, M."Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck". International Journal of Oncology 34, no. 2 (2009): 321-327. https://doi.org/10.3892/ijo_00000154
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura M, Kato Y, Sano D, Fujita K, Sakakibara A, Kondo N, Mikami Y and Tsukuda M: Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. Int J Oncol 34: 321-327, 2009.
APA
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N. ... Tsukuda, M. (2009). Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. International Journal of Oncology, 34, 321-327. https://doi.org/10.3892/ijo_00000154
MLA
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N., Mikami, Y., Tsukuda, M."Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck". International Journal of Oncology 34.2 (2009): 321-327.
Chicago
Kimura, M., Kato, Y., Sano, D., Fujita, K., Sakakibara, A., Kondo, N., Mikami, Y., Tsukuda, M."Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck". International Journal of Oncology 34, no. 2 (2009): 321-327. https://doi.org/10.3892/ijo_00000154
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