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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2009 Volume 34 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 34 Issue 2

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Article

Epigenetic regulation of hTERT promoter in hepatocellular carcinomas

  • Authors:
    • Dimitrios Iliopoulos
    • Maria Satra
    • Alexandra Drakaki
    • George A. Poultsides
    • Aspasia Tsezou

  • View Affiliations / Copyright

    Affiliations: Institute of Biomedical Research and Technology, Larissa, Greece
  • Pages: 391-399
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/ijo_00000162
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Abstract

Although hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, the molecular pathogenesis of the disease has not been elucidated. Several studies have shown that telomerase activity and hTERT expression are increased in HCCs. In the present study we tried to elucidate hTERT transcriptional and epigenetic regulatory mechanisms in HCC. hTERT expression was tested by real-time PCR and DNA methylation status was assessed by MethyLight and DNA bisulfite sequencing analyses in 106 tissues (64 with HCC and 42 without liver disorders) and also in 7 hepatocarcinoma cell lines (HepG2, HepG3B2, C3A, SNU-182, SNU-398, SBU-449 and SNU-475). hTERT expression levels were inversely correlated with DNA methylation levels in HCC and normal tissues (r=−0.859). hTERT expression was found to be regulated by DNA methylation and histone H3-K9 modifications, affecting the ability of c-myc binding in E-box 1 site in hTERT promoter. Additionally, c-myc siRNA liposomal down-regulation inhibited significantly hTERT expression (p<0.05). Thus, we propose that hTERT is regulated by a combination of epigenetic mechanisms (DNA methylation and histone modifications) and by the transcription factor c-myc in HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Iliopoulos D, Satra M, Drakaki A, Poultsides GA and Tsezou A: Epigenetic regulation of hTERT promoter in hepatocellular carcinomas. Int J Oncol 34: 391-399, 2009.
APA
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G.A., & Tsezou, A. (2009). Epigenetic regulation of hTERT promoter in hepatocellular carcinomas. International Journal of Oncology, 34, 391-399. https://doi.org/10.3892/ijo_00000162
MLA
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G. A., Tsezou, A."Epigenetic regulation of hTERT promoter in hepatocellular carcinomas". International Journal of Oncology 34.2 (2009): 391-399.
Chicago
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G. A., Tsezou, A."Epigenetic regulation of hTERT promoter in hepatocellular carcinomas". International Journal of Oncology 34, no. 2 (2009): 391-399. https://doi.org/10.3892/ijo_00000162
Copy and paste a formatted citation
x
Spandidos Publications style
Iliopoulos D, Satra M, Drakaki A, Poultsides GA and Tsezou A: Epigenetic regulation of hTERT promoter in hepatocellular carcinomas. Int J Oncol 34: 391-399, 2009.
APA
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G.A., & Tsezou, A. (2009). Epigenetic regulation of hTERT promoter in hepatocellular carcinomas. International Journal of Oncology, 34, 391-399. https://doi.org/10.3892/ijo_00000162
MLA
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G. A., Tsezou, A."Epigenetic regulation of hTERT promoter in hepatocellular carcinomas". International Journal of Oncology 34.2 (2009): 391-399.
Chicago
Iliopoulos, D., Satra, M., Drakaki, A., Poultsides, G. A., Tsezou, A."Epigenetic regulation of hTERT promoter in hepatocellular carcinomas". International Journal of Oncology 34, no. 2 (2009): 391-399. https://doi.org/10.3892/ijo_00000162
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