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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2009 Volume 34 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 34 Issue 2

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Article

Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women

  • Authors:
    • Baoxia Cui
    • Biying Zheng
    • Xi Zhang
    • Ulf Stendahl
    • Sonia Andersson
    • Keng-Ling Wallin

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden. baoxiacui@hotmail.com
  • Pages: 409-416
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/ijo_00000164
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Abstract

PIK3CA encodes the p110α catalytic subunit of PI 3-kinase, which regulates signaling pathways important for neoplasia, cell proliferation and apoptosis. Somatic mutations in this gene have been detected in several solid human tumors. We investigated these mutations in cervical carcinoma and its precursors, and their association with HPV infection and patient clinical data. The mutations were analyzed using post-PCR direct genomic DNA sequencing. Samples included 9 cervical cancer cell lines, 184 invasive cervical carcinomas, and 30 cervical neoplasias. Missense mutations of PIK3CA were identified in 15/184 (8.15%) invasive cervical carcinomas. One novel mutation G1638C (Q546H) was found. Three mutations were identified in the cervical cancer lines. No mutations were found in the precursors. The difference in mutation frequency between invasive and pre-invavasive lesions was not significant (p=0.1372). In relation to age and HPV, the mutation rate was significantly higher in patients ≥60 years (p=0.001), while the rate of HPV infection was higher in patients ≤60 years (p=0.025). No significant correlation with other clinicopathological data was found. The results suggest that PIK3CA mutations are a late event and uncommon in the progression of malignant tumors, but it appears that they facilitate carcinogenesis in older women.

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Copy and paste a formatted citation
Spandidos Publications style
Cui B, Zheng B, Zhang X, Stendahl U, Andersson S and Wallin K: Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women. Int J Oncol 34: 409-416, 2009.
APA
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., & Wallin, K. (2009). Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women. International Journal of Oncology, 34, 409-416. https://doi.org/10.3892/ijo_00000164
MLA
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., Wallin, K."Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women". International Journal of Oncology 34.2 (2009): 409-416.
Chicago
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., Wallin, K."Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women". International Journal of Oncology 34, no. 2 (2009): 409-416. https://doi.org/10.3892/ijo_00000164
Copy and paste a formatted citation
x
Spandidos Publications style
Cui B, Zheng B, Zhang X, Stendahl U, Andersson S and Wallin K: Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women. Int J Oncol 34: 409-416, 2009.
APA
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., & Wallin, K. (2009). Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women. International Journal of Oncology, 34, 409-416. https://doi.org/10.3892/ijo_00000164
MLA
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., Wallin, K."Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women". International Journal of Oncology 34.2 (2009): 409-416.
Chicago
Cui, B., Zheng, B., Zhang, X., Stendahl, U., Andersson, S., Wallin, K."Mutation of PIK3CA: Possible risk factor for cervical carcinogenesis in older women". International Journal of Oncology 34, no. 2 (2009): 409-416. https://doi.org/10.3892/ijo_00000164
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