Capability of SART3109-118 peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles

Mohamed,Elnisr Rashed; Naito,Masayasu; Terasaki,Yasunobu; Niu,Yamei; Gohara,Shojiro; Komatsu,Nobukazu; Shichijo,Shigeki; Itoh,Kyogo; Noguchi,Masanori

doi:10.3892/ijo_00000178

February 2009 Volume 34 Issue 2

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February 2009 Volume 34 Issue 2

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Article

Capability of SART3109-118 peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles

Authors:
- Elnisr Rashed Mohamed
- Masayasu Naito
- Yasunobu Terasaki
- Yamei Niu
- Shojiro Gohara
- Nobukazu Komatsu
- Shigeki Shichijo
- Kyogo Itoh
- Masanori Noguchi
View Affiliations / Copyright

Affiliations: Department of Urology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan
Pages: 529-536
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Published online on: February 1, 2009

https://doi.org/10.3892/ijo_00000178
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Abstract

We previously reported the SART3 gene to be a tumor-rejection antigen gene encoding a peptide at positions 109-118 (SART3109-118) with the ability to induce HLA-A24-restricted cytotoxic T lymphocytes. In this study, we investigated both humoral and cellular responses to this peptide in cancer patients with alleles other than HLA-A24 to explore the possibility of using this peptide as a cancer vaccine for these patients. IgG reactive to SART3109-118 peptide was identified in sera of the vast majority of non-cancer subjects (n=50) and all cancer patients (n=50) tested without apparent HLA-A association. Levels of anti-SART3109-118 peptide antibody in cancer patients were significantly higher than those of non-cancer subjects, but no difference was found between HLA-A24+A2− and HLA-A24−A2+ cancer patients. This peptide induced cancer cell-reactive cytotoxic T lymphocytes from peripheral blood mononuclear cells of both healthy donors and prostate cancer patients with HLA-A11, HLA-A31 and HLA-A33 alleles, but not with HLA-A2. These results suggest that this peptide can be applicable as a cancer vaccine not only for HLA-A24+, but also for HLA-A11+, HLA-A31+ and HLA-A33+ prostate cancer patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Capability of SART3109-118 peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles

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Abstract

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