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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2009 Volume 34 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 34 Issue 2

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Article

The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression

  • Authors:
    • H. B. Liu
    • M. T. Voso
    • D. Gumiero
    • J. Duong
    • J. J. McKendrick
    • A. E. Dear

  • View Affiliations / Copyright

    Affiliations: Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Monash University, Prahran 3181, Melbourne, Victoria, Australia
  • Pages: 573-579
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/ijo_00000183
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Abstract

A combination of demethylating agents and histone deacetylase inhibitors (HDACi) has been proposed as a novel therapy in leukemia and myelodysplasia. In HL-60 cells azacytidine (AZA) and Metacept-1 (MCT-1), a novel HDACi augmented inhibition of cell growth and increased apoptosis. In identifying a molecular mechanism responsible for these effects MCT-1 alone and in combination with AZA induced p15INK4b, p21WAF1/CIP1 and Caspase-3 whilst attenuating Bcl-XL expression. Interestingly, MCT-1 in combination with AZA significantly induced the recently identified suppressor of leukemogenesis Nur77 and attenuated AZA-induced MMP-9 expression. The combination of MCT-1 and AZA is more effective in inhibiting leukemic cell growth and induction of apoptosis. Regulation of a recently identified tumour suppressor gene together with cell cycle, apoptosis and matrix degrading proteases may underpin the molecular mechanism responsible for these effects.

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Copy and paste a formatted citation
Spandidos Publications style
Liu HB, Voso MT, Gumiero D, Duong J, McKendrick JJ and Dear AE: The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression. Int J Oncol 34: 573-579, 2009.
APA
Liu, H.B., Voso, M.T., Gumiero, D., Duong, J., McKendrick, J.J., & Dear, A.E. (2009). The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression. International Journal of Oncology, 34, 573-579. https://doi.org/10.3892/ijo_00000183
MLA
Liu, H. B., Voso, M. T., Gumiero, D., Duong, J., McKendrick, J. J., Dear, A. E."The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression". International Journal of Oncology 34.2 (2009): 573-579.
Chicago
Liu, H. B., Voso, M. T., Gumiero, D., Duong, J., McKendrick, J. J., Dear, A. E."The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression". International Journal of Oncology 34, no. 2 (2009): 573-579. https://doi.org/10.3892/ijo_00000183
Copy and paste a formatted citation
x
Spandidos Publications style
Liu HB, Voso MT, Gumiero D, Duong J, McKendrick JJ and Dear AE: The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression. Int J Oncol 34: 573-579, 2009.
APA
Liu, H.B., Voso, M.T., Gumiero, D., Duong, J., McKendrick, J.J., & Dear, A.E. (2009). The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression. International Journal of Oncology, 34, 573-579. https://doi.org/10.3892/ijo_00000183
MLA
Liu, H. B., Voso, M. T., Gumiero, D., Duong, J., McKendrick, J. J., Dear, A. E."The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression". International Journal of Oncology 34.2 (2009): 573-579.
Chicago
Liu, H. B., Voso, M. T., Gumiero, D., Duong, J., McKendrick, J. J., Dear, A. E."The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression". International Journal of Oncology 34, no. 2 (2009): 573-579. https://doi.org/10.3892/ijo_00000183
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