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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2009 Volume 34 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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Article

Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC

  • Authors:
    • Takaki Hiwasa
    • Hideaki Shimada
    • Mari Kuboshima
    • Tooru Shiratori
    • Akiko Kagaya
    • Yoshihiro Nabeya
    • Sumio Sugano
    • Takenori Ochiai
    • Hisahiro Matsubara
    • Masaki Takiguchi

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Genetics, Chiba University, Graduate School of Medicine, Chuo-ku, Chiba 260-8670, Japan. hiwasa_takaki@faculty.chiba-u.jp
  • Pages: 641-648
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/ijo_00000189
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Abstract

We performed SEREX (serological identification of antigens by recombinant cDNA expression cloning) using the sera of patients with esophageal squamous cell carcinoma (SCC), and examined whether some of the SEREX antigens can affect chemosensitivity against anticancer drugs. We isolated a novel gene which was designated as AISEC (antigen identified by SEREX for esophageal carcinoma). RT-PCR analysis showed that the mRNA expression levels of AISEC were higher in esophageal SCC tissues than in their normal counterparts. By transfection into activated Ha-ras-transformed NIH3T3 (ras-NIH) mouse fibroblasts, we isolated a clone, FAISEC-3, which stably expressed AISEC. FAISEC-3 cells were more resistant to anticancer drugs, such as mitomycin C, ifosfamide, vincristine, camptothecin and etoposide, than parental ras-NIH cells. Luciferase reporter assay after a transient transfection with AISEC cDNA or the control vector revealed that the transactivity of p53 was suppressed by AISEC in a dose-dependent manner. These results suggested that esophageal SCC tissues produce AISEC in increased amounts, which can reduce the chemosensitivity against anticancer drugs possibly by suppressing the p53 transactivation ability.

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Copy and paste a formatted citation
Spandidos Publications style
Hiwasa T, Shimada H, Kuboshima M, Shiratori T, Kagaya A, Nabeya Y, Sugano S, Ochiai T, Matsubara H, Takiguchi M, Takiguchi M, et al: Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. Int J Oncol 34: 641-648, 2009.
APA
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y. ... Takiguchi, M. (2009). Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. International Journal of Oncology, 34, 641-648. https://doi.org/10.3892/ijo_00000189
MLA
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H., Takiguchi, M."Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC". International Journal of Oncology 34.3 (2009): 641-648.
Chicago
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H., Takiguchi, M."Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC". International Journal of Oncology 34, no. 3 (2009): 641-648. https://doi.org/10.3892/ijo_00000189
Copy and paste a formatted citation
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Spandidos Publications style
Hiwasa T, Shimada H, Kuboshima M, Shiratori T, Kagaya A, Nabeya Y, Sugano S, Ochiai T, Matsubara H, Takiguchi M, Takiguchi M, et al: Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. Int J Oncol 34: 641-648, 2009.
APA
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y. ... Takiguchi, M. (2009). Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC. International Journal of Oncology, 34, 641-648. https://doi.org/10.3892/ijo_00000189
MLA
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H., Takiguchi, M."Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC". International Journal of Oncology 34.3 (2009): 641-648.
Chicago
Hiwasa, T., Shimada, H., Kuboshima, M., Shiratori, T., Kagaya, A., Nabeya, Y., Sugano, S., Ochiai, T., Matsubara, H., Takiguchi, M."Decrease in chemosensitivity against anticancer drugs by an esophageal squamous cell carcinoma SEREX antigen, AISEC". International Journal of Oncology 34, no. 3 (2009): 641-648. https://doi.org/10.3892/ijo_00000189
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