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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2009 Volume 34 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2009 Volume 34 Issue 5

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Article

Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer

  • Authors:
    • Sateesh Kunigal
    • Sajani S. Lakka
    • Prasanna Kumar Sodadasu
    • Norman Estes
    • Jasti S. Rao

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
  • Pages: 1209-1220
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/ijo_00000249
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Abstract

Stat3, a member of the signal transducer and activator of transcription family, has the potential to mediate cell survival, growth and differentiation. Stat3 is constitutively activated in numerous cancers, including >50% of breast cancers. Previous studies demonstrated that constitutively activated Stat3 plays an important role in breast cancer development and progression by promoting cell proliferation and inhibiting apoptosis. The present study was designed to investigate the potential use of RNA interference (RNAi) to block Stat3 expression and activation, as well as the subsequent effect on human breast cancer cell growth. Our studies show that knockdown of STAT3 expression by siRNA reduced expression of Bcl-xL and survivin in MDA-MB-231 cells, and also led to Fas mediated intrinsic apoptotic pathway by activating caspases -8, -9, -3 and PARP1 cleavage. In nude mice, pRNAi-Stat3 significantly suppressed tumor growth compared with controls. It also suppressed Stat3 expression, and downregulated BcL-xL and upregulated Fas, Fas-L and cleaved caspase-3 expression within the tumor, which significantly induced apoptosis and led to tumor suppression. Thus, targeting Stat3 signaling using siRNA may serve as a novel therapeutic strategy for the treatment of breast cancers expressing constitutively activated Stat3.

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Copy and paste a formatted citation
Spandidos Publications style
Kunigal S, Lakka SS, Sodadasu PK, Estes N and Rao JS: Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int J Oncol 34: 1209-1220, 2009.
APA
Kunigal, S., Lakka, S.S., Sodadasu, P.K., Estes, N., & Rao, J.S. (2009). Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International Journal of Oncology, 34, 1209-1220. https://doi.org/10.3892/ijo_00000249
MLA
Kunigal, S., Lakka, S. S., Sodadasu, P. K., Estes, N., Rao, J. S."Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer". International Journal of Oncology 34.5 (2009): 1209-1220.
Chicago
Kunigal, S., Lakka, S. S., Sodadasu, P. K., Estes, N., Rao, J. S."Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer". International Journal of Oncology 34, no. 5 (2009): 1209-1220. https://doi.org/10.3892/ijo_00000249
Copy and paste a formatted citation
x
Spandidos Publications style
Kunigal S, Lakka SS, Sodadasu PK, Estes N and Rao JS: Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int J Oncol 34: 1209-1220, 2009.
APA
Kunigal, S., Lakka, S.S., Sodadasu, P.K., Estes, N., & Rao, J.S. (2009). Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. International Journal of Oncology, 34, 1209-1220. https://doi.org/10.3892/ijo_00000249
MLA
Kunigal, S., Lakka, S. S., Sodadasu, P. K., Estes, N., Rao, J. S."Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer". International Journal of Oncology 34.5 (2009): 1209-1220.
Chicago
Kunigal, S., Lakka, S. S., Sodadasu, P. K., Estes, N., Rao, J. S."Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer". International Journal of Oncology 34, no. 5 (2009): 1209-1220. https://doi.org/10.3892/ijo_00000249
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