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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2009 Volume 34 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2009 Volume 34 Issue 5

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Article

Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells

  • Authors:
    • Munirathinam Gnanasekar
    • Sivasakthivel Thirugnanam
    • Guoxing Zheng
    • Aoshuang Chen
    • Kalyanasundaram Ramaswamy

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107, USA. mgnanas@uic.edu
  • Pages: 1241-1246
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/ijo_00000252
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Abstract

Translationally controlled tumor protein (TCTP) is a novel anti apoptotic protein which is highly expressed in several cancer cell types including prostate cancer. However, studies investigating the role of TCTP in prostate cancer are scarce. Therefore, in this study we evaluated the effect of small interference RNA (siRNA) based knocking down of TCTP gene in prostate cancer cells. Cell proliferation and apoptosis were evaluated. Our results showed that TCTP is highly expressed in LNCaP cells compared to normal prostate epithelial cells. Transfection with TCTP siRNA specifically and drastically reduced the expression of both mRNA and protein levels of TCTP in LNCaP cells. The decreased expression of TCTP was associated with decreased viability of LNCaP cells. Further analysis of the transfected LNCaP cells showed that they undergo apoptosis via caspase-8 and caspase-3 dependent pathways. Results presented herein suggest a potential therapeutic application for prostate cancer by targeting TCTP gene using an siRNA approach.

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Copy and paste a formatted citation
Spandidos Publications style
Gnanasekar M, Thirugnanam S, Zheng G, Chen A and Ramaswamy K: Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. Int J Oncol 34: 1241-1246, 2009.
APA
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., & Ramaswamy, K. (2009). Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. International Journal of Oncology, 34, 1241-1246. https://doi.org/10.3892/ijo_00000252
MLA
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., Ramaswamy, K."Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells". International Journal of Oncology 34.5 (2009): 1241-1246.
Chicago
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., Ramaswamy, K."Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells". International Journal of Oncology 34, no. 5 (2009): 1241-1246. https://doi.org/10.3892/ijo_00000252
Copy and paste a formatted citation
x
Spandidos Publications style
Gnanasekar M, Thirugnanam S, Zheng G, Chen A and Ramaswamy K: Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. Int J Oncol 34: 1241-1246, 2009.
APA
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., & Ramaswamy, K. (2009). Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. International Journal of Oncology, 34, 1241-1246. https://doi.org/10.3892/ijo_00000252
MLA
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., Ramaswamy, K."Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells". International Journal of Oncology 34.5 (2009): 1241-1246.
Chicago
Gnanasekar, M., Thirugnanam, S., Zheng, G., Chen, A., Ramaswamy, K."Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells". International Journal of Oncology 34, no. 5 (2009): 1241-1246. https://doi.org/10.3892/ijo_00000252
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