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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2009 Volume 34 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2009 Volume 34 Issue 5

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Article

Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines

  • Authors:
    • Hiromasa Fujii
    • Kanya Honoki
    • Toshifumi Tsujiuchi
    • Akira Kido
    • Kazuhiro Yoshitani
    • Yoshinori Takakura

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634-8521, Japan
  • Pages: 1381-1386
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/ijo_00000265
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Abstract

The presence of cancer stem cells in both solid and hematopoietic malignancies, has been recently linked to their pathogenesis. Sarcomas are rare, and diversely characterized by degrees of mesenchymal differentiation. The aim of the current study was to demonstrate whether the human sarcoma cell lines, osteosarcoma MG63, Ewing's sarcoma HTB166, fibrosarcoma HT1080, possess the stem-like properties which may contribute to the drug-resistance. All cell lines possessed an ability to form spherical, clonal expanding colonies (sarcospheres) in anchorage-independent, serum-starved conditions. Sarcospheres showed the stem-like properties with the ability of self-renewal, and increased expression of the stem cell-related genes such as Nanog, OCT3/4 SOX2 and DNA repair enzyme genes, MLH1 and MSH2. Sarcospheres showed strong resistance to doxorubicin and cisplatin, and caffeine, a DNA repair inhibitor, enhanced the efficacy of those drugs, suggesting that the drug resistance in sarcosphere cells was partly related to the efficient DNA repair ability. These results indicate that human sarcoma cell lines contain stem-like cell populations with strong drug resistance, and DNA repair inhibitor could enhance the efficacy of chemo-drugs against sarcomas.

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Copy and paste a formatted citation
Spandidos Publications style
Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K and Takakura Y: Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol 34: 1381-1386, 2009.
APA
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., & Takakura, Y. (2009). Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. International Journal of Oncology, 34, 1381-1386. https://doi.org/10.3892/ijo_00000265
MLA
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., Takakura, Y."Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines". International Journal of Oncology 34.5 (2009): 1381-1386.
Chicago
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., Takakura, Y."Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines". International Journal of Oncology 34, no. 5 (2009): 1381-1386. https://doi.org/10.3892/ijo_00000265
Copy and paste a formatted citation
x
Spandidos Publications style
Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K and Takakura Y: Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol 34: 1381-1386, 2009.
APA
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., & Takakura, Y. (2009). Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. International Journal of Oncology, 34, 1381-1386. https://doi.org/10.3892/ijo_00000265
MLA
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., Takakura, Y."Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines". International Journal of Oncology 34.5 (2009): 1381-1386.
Chicago
Fujii, H., Honoki, K., Tsujiuchi, T., Kido, A., Yoshitani, K., Takakura, Y."Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines". International Journal of Oncology 34, no. 5 (2009): 1381-1386. https://doi.org/10.3892/ijo_00000265
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