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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2009 Volume 34 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2009 Volume 34 Issue 6

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Article

Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening

  • Authors:
    • Su-Jin Lee
    • Youn-Sang Jung
    • Sun-Hye Lee
    • Hye-Young Chung
    • Bum-Joon Park

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology, College of Natural Science, Pusan National University, Jangjeon-dong, Geumjoung-gu, Busan, Korea
  • Pages: 1637-1643
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/ijo_00000294
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Abstract

The strong tumor suppressor p53 shows loss of function in large portion of human cancer. In addition to genetic mutation, biological function of p53 is suppressed by signaling distortion or elevated expression of p53 inhibitors (such as overexpression of MDM2 or deletion of p14/ARF). In this study, we demonstrate that K-Ras, a frequently altered oncogene in human cancers including pancreatic cancer (about 80%), colon cancer (45%) and lung cancer (45%), suppresses p53. Based on this fact, we perform Western blot analysis-based chemical screening to isolate a K-Ras-specific activator of p53. From 117 kinds of chemicals (34 kinds of natural compounds that are obtained from herbal plants, 53 kinds of flavonoid, and 31 kinds of phenolic compounds), we find that quercetin works as an activator of p53 in K-Ras mutated cells but not in wild-type cells. Treatment with quercetin can induce p53 target genes such as PUMA and p21. These results suggest that although quercetin has limitations for use as a therapeutic drug due to its broad effects, specific function of it on K-Ras-p53 may be useful for K-Ras-induced cancer prevention and therapy through further development.

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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Jung Y, Lee S, Chung H and Park B: Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. Int J Oncol 34: 1637-1643, 2009.
APA
Lee, S., Jung, Y., Lee, S., Chung, H., & Park, B. (2009). Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. International Journal of Oncology, 34, 1637-1643. https://doi.org/10.3892/ijo_00000294
MLA
Lee, S., Jung, Y., Lee, S., Chung, H., Park, B."Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening". International Journal of Oncology 34.6 (2009): 1637-1643.
Chicago
Lee, S., Jung, Y., Lee, S., Chung, H., Park, B."Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening". International Journal of Oncology 34, no. 6 (2009): 1637-1643. https://doi.org/10.3892/ijo_00000294
Copy and paste a formatted citation
x
Spandidos Publications style
Lee S, Jung Y, Lee S, Chung H and Park B: Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. Int J Oncol 34: 1637-1643, 2009.
APA
Lee, S., Jung, Y., Lee, S., Chung, H., & Park, B. (2009). Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening. International Journal of Oncology, 34, 1637-1643. https://doi.org/10.3892/ijo_00000294
MLA
Lee, S., Jung, Y., Lee, S., Chung, H., Park, B."Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening". International Journal of Oncology 34.6 (2009): 1637-1643.
Chicago
Lee, S., Jung, Y., Lee, S., Chung, H., Park, B."Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening". International Journal of Oncology 34, no. 6 (2009): 1637-1643. https://doi.org/10.3892/ijo_00000294
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