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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2009 Volume 34 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2009 Volume 34 Issue 6

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Article

MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation

  • Authors:
    • Li Yin
    • Surender Kharbanda
    • Donald Kufe

  • View Affiliations / Copyright

    Affiliations: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 1691-1699
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/ijo_00000300
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Abstract

Tumor cells survive under conditions of nutrient deprivation by mechanisms that are not fully understood. The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and blocks oxidative stress-induced death. The present studies show that MUC1 inhibits the induction of necrosis in response to the deprivation of glucose. MUC1 suppressed glucose deprivation-induced increases in reactive oxygen species (ROS) and thereby depletion of ATP and cell death. Cells respond to oxidative stress and energy depletion with the induction of autophagy. Our results demonstrate that MUC1 blocks depletion of ATP and sustains growth of glucose-deprived cells by a mechanism sensitive to the autophagy inhibitor, 3-methyladenine. Silencing expression of ATG7, a protein essential for the formation of autophagic vacuoles, also attenuated the MUC1-sustained increases in ATP and growth in response to glucose deprivation. Moreover, we found that MUC1 stimulates AMPK activation and thereby promotes lysosomal turnover of LC3-II, a marker of starvation-induced autophagic activity. These results indicate that MUC1 suppresses glucose deprivation-induced increases in ROS and thereby promotes ATP production and survival. The findings also indicate that the overexpression of MUC1 as found in human cancers could provide a survival advantage in microenvironments with low glucose levels.

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Copy and paste a formatted citation
Spandidos Publications style
Yin L, Kharbanda S and Kufe D: MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol 34: 1691-1699, 2009.
APA
Yin, L., Kharbanda, S., & Kufe, D. (2009). MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. International Journal of Oncology, 34, 1691-1699. https://doi.org/10.3892/ijo_00000300
MLA
Yin, L., Kharbanda, S., Kufe, D."MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation". International Journal of Oncology 34.6 (2009): 1691-1699.
Chicago
Yin, L., Kharbanda, S., Kufe, D."MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation". International Journal of Oncology 34, no. 6 (2009): 1691-1699. https://doi.org/10.3892/ijo_00000300
Copy and paste a formatted citation
x
Spandidos Publications style
Yin L, Kharbanda S and Kufe D: MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol 34: 1691-1699, 2009.
APA
Yin, L., Kharbanda, S., & Kufe, D. (2009). MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. International Journal of Oncology, 34, 1691-1699. https://doi.org/10.3892/ijo_00000300
MLA
Yin, L., Kharbanda, S., Kufe, D."MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation". International Journal of Oncology 34.6 (2009): 1691-1699.
Chicago
Yin, L., Kharbanda, S., Kufe, D."MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation". International Journal of Oncology 34, no. 6 (2009): 1691-1699. https://doi.org/10.3892/ijo_00000300
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