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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2009 Volume 35 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 35 Issue 1

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Article

CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer

  • Authors:
    • Takaaki Arigami
    • Shoji Natsugoe
    • Yoshikazu Uenosono
    • Shigehiro Yanagita
    • Hideo Arima
    • Munetsugu Hirata
    • Sumiya Ishigami
    • Takashi Aikou

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology and Digestive Surgery, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan. arigami@m.kufm.kagoshima-u.ac.jp
  • Pages: 19-24
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/ijo_00000308
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Abstract

The chemokine receptors CCR7 and CXCR4 play a major role in the mechanism of lymph node metastasis from primary tumor cells. We postulated that their expression in gastric tumor cells could predict lymph node status including lymph node micrometastasis (LNMM). We assessed CCR7 and CXCR4 expression in 93 resected gastric tumor specimens by immunohistochemistry. Dissected lymph nodes were examined by reverse transcription-polymerase chain reaction and immunohistochemistry using cytokeratin monoclonal antibody to detect LNMM in addition to hematoxylin-eosin (H&E) staining. Levels of CCR7 and CXCR4 expression were high in 26.9% (25/93) and in 32.3% (30/93), respectively of tumor cells and the levels significantly correlated with lymph node metastasis according to H&E staining (P=0.0212 and P=0.0115, respectively). We identified LNMM in 25 of 83 (30.1%) node-negative patients. Both CCR7 and CXCR4 expression significantly correlated with lymph node status including LNMM (P=0.0092 and P=0.0075, respectively). Furthermore, levels of combined CCR7 and CXCR4 expression significantly correlated with lymph node metastatic status (P=0.0021). Assessment of CCR7 and CXCR4 expression in gastric cancer is a useful tool for predicting lymph node metastatic status including LNMM.

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Copy and paste a formatted citation
Spandidos Publications style
Arigami T, Natsugoe S, Uenosono Y, Yanagita S, Arima H, Hirata M, Ishigami S and Aikou T: CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol 35: 19-24, 2009.
APA
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M. ... Aikou, T. (2009). CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. International Journal of Oncology, 35, 19-24. https://doi.org/10.3892/ijo_00000308
MLA
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M., Ishigami, S., Aikou, T."CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer". International Journal of Oncology 35.1 (2009): 19-24.
Chicago
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M., Ishigami, S., Aikou, T."CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer". International Journal of Oncology 35, no. 1 (2009): 19-24. https://doi.org/10.3892/ijo_00000308
Copy and paste a formatted citation
x
Spandidos Publications style
Arigami T, Natsugoe S, Uenosono Y, Yanagita S, Arima H, Hirata M, Ishigami S and Aikou T: CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol 35: 19-24, 2009.
APA
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M. ... Aikou, T. (2009). CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. International Journal of Oncology, 35, 19-24. https://doi.org/10.3892/ijo_00000308
MLA
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M., Ishigami, S., Aikou, T."CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer". International Journal of Oncology 35.1 (2009): 19-24.
Chicago
Arigami, T., Natsugoe, S., Uenosono, Y., Yanagita, S., Arima, H., Hirata, M., Ishigami, S., Aikou, T."CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer". International Journal of Oncology 35, no. 1 (2009): 19-24. https://doi.org/10.3892/ijo_00000308
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