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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2009 Volume 35 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 35 Issue 1

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Article

The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma

  • Authors:
    • Jun Yu
    • Etmar Bulk
    • Ping Ji
    • Antje Hascher
    • Steffen Koschmieder
    • Wolfgang E. Berdel
    • Carsten Müller-Tidow

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Hematology and Oncology, University of Münster, D-48129 Münster, Germany
  • Pages: 175-179
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/ijo_00000326
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Abstract

Decreased expression levels of EPHB6, a member of the receptor tyrosine kinases (RTKs), are associated with an increased risk of metastasis development in early stage non-small cell lung cancer (NSCLC). However, the signaling properties of the kinase-defective EPHB6 receptor are not well-understood. Here, we show that expression of EPHB6 in A549 lung adenocarinoma cells led to phosphorylation of the MAP kinase ERK. Conversely, siRNA based knockdown of EPHB6 reversed ERK phosphorylation. Intriguingly, EPHB6-induced phosphorylation of ERK was uncoupled by activation of the Elk-1 transcriptional factor. These analyses suggest that kinase defective EPHB6 can lead to MAPK activation.

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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Bulk E, Ji P, Hascher A, Koschmieder S, Berdel WE and Müller-Tidow C: The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. Int J Oncol 35: 175-179, 2009.
APA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W.E., & Müller-Tidow, C. (2009). The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. International Journal of Oncology, 35, 175-179. https://doi.org/10.3892/ijo_00000326
MLA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35.1 (2009): 175-179.
Chicago
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35, no. 1 (2009): 175-179. https://doi.org/10.3892/ijo_00000326
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Bulk E, Ji P, Hascher A, Koschmieder S, Berdel WE and Müller-Tidow C: The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. Int J Oncol 35: 175-179, 2009.
APA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W.E., & Müller-Tidow, C. (2009). The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. International Journal of Oncology, 35, 175-179. https://doi.org/10.3892/ijo_00000326
MLA
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35.1 (2009): 175-179.
Chicago
Yu, J., Bulk, E., Ji, P., Hascher, A., Koschmieder, S., Berdel, W. E., Müller-Tidow, C."The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma". International Journal of Oncology 35, no. 1 (2009): 175-179. https://doi.org/10.3892/ijo_00000326
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