Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope

  • Authors:
    • Seiji Yanai
    • Yasushi Adachi
    • Jun-Ichi Fuijisawa
    • Shiwen Jiang
    • Mitsuhiko Okigaki
    • Ming Shi
    • Chieko Shima
    • Yuichiro Imai
    • A-Hon Kwon
    • Susumu Ikehara
  • View Affiliations

  • Published online on: August 1, 2009     https://doi.org/10.3892/ijo_00000334
  • Pages: 249-255
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Abstract

It has been reported that the fusion cells of dendritic cells (DCs) and tumor cells have anti-tumor effects. In this experiment, we examined the anti-tumor effects of fusion cells of bone marrow-derived DC type 1 (DC1) and irradiated tumor cells using a newly commercially available hemagglutinating virus of Japan-envelope (HVJ-E) after cell fusion, in a mouse model. To induce DC1, bone marrow cells (BMCs) from BALB/c mice were cultured with GM-CSF, IL-12 and IFN-γ. BMC-derived DC1 were fused with 20-Gy-irradiated Meth A cells (BALB/c-derived fibrosarcoma) using HVJ-E. We subcutaneously injected: i) the BMC-derived DC1, or ii) the fusion cells of the DC1 and the irradiated Meth A cells, into Meth A-bearing BALB/c mice. The injection of only DC1 showed a moderate anti-tumor effect, as we previously described. However, the fusion cells were more effective in not only suppressing tumor growth but also prolonging survival. These results suggest that the fusion cells of DC1 and the irradiated tumor cells using HVJ-E were more effective in tumor suppression than DC1 alone.

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August 2009
Volume 35 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yanai S, Adachi Y, Fuijisawa J, Jiang S, Okigaki M, Shi M, Shima C, Imai Y, Kwon A, Ikehara S, Ikehara S, et al: Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope. Int J Oncol 35: 249-255, 2009
APA
Yanai, S., Adachi, Y., Fuijisawa, J., Jiang, S., Okigaki, M., Shi, M. ... Ikehara, S. (2009). Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope. International Journal of Oncology, 35, 249-255. https://doi.org/10.3892/ijo_00000334
MLA
Yanai, S., Adachi, Y., Fuijisawa, J., Jiang, S., Okigaki, M., Shi, M., Shima, C., Imai, Y., Kwon, A., Ikehara, S."Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope". International Journal of Oncology 35.2 (2009): 249-255.
Chicago
Yanai, S., Adachi, Y., Fuijisawa, J., Jiang, S., Okigaki, M., Shi, M., Shima, C., Imai, Y., Kwon, A., Ikehara, S."Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope". International Journal of Oncology 35, no. 2 (2009): 249-255. https://doi.org/10.3892/ijo_00000334