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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2009 Volume 35 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2009 Volume 35 Issue 2

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Article

Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling

  • Authors:
    • Hong Yuan
    • Satoko Ito
    • Takeshi Senga
    • Toshinori Hyodo
    • Tohru Kiyono
    • Fumitaka Kikkawa
    • Michinari Hamaguchi

  • View Affiliations / Copyright

    Affiliations: Division of Cancer Biology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan
  • Pages: 309-314
    |
    Published online on: August 1, 2009
       https://doi.org/10.3892/ijo_00000341
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Abstract

Human papillomaviruses (HPV) are the main etiological factor for cervical carcinoma. HPV-16 is the most prevalent high-risk HPV-genotype found in HPV-associated cancers. We studied the effect of HPV-16 E7 oncoprotein on cadherin-mediated cell adhesion. The expression of E7 strongly suppressed the cadherin-mediated cell adhesion in the rat fibroblast cell line 3Y1. This suppression was associated with the decreased expression of N-cadherin at the transcriptional level. The treatment of 3Y1 cells that express E7 (E7-3Y1) with MEK inhibitor recovered the cadherin-mediated cell adhesion together with the accumulation of N-cadherin at the cell-cell contact site. Moreover, the suppression of c-Jun, which is the element of AP-1 transcriptional factor, leads to the recovery of N-cadherin expression and cadherin-mediated cell adhesion in E7-3Y1 cells. Taken together, our results demonstrate that E7 regulates cadherin-mediated cell adhesion through the modulation of cadherin expression via the MEK-ERK and AP-1 signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Yuan H, Ito S, Senga T, Hyodo T, Kiyono T, Kikkawa F and Hamaguchi M: Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. Int J Oncol 35: 309-314, 2009.
APA
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., & Hamaguchi, M. (2009). Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. International Journal of Oncology, 35, 309-314. https://doi.org/10.3892/ijo_00000341
MLA
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., Hamaguchi, M."Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling". International Journal of Oncology 35.2 (2009): 309-314.
Chicago
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., Hamaguchi, M."Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling". International Journal of Oncology 35, no. 2 (2009): 309-314. https://doi.org/10.3892/ijo_00000341
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan H, Ito S, Senga T, Hyodo T, Kiyono T, Kikkawa F and Hamaguchi M: Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. Int J Oncol 35: 309-314, 2009.
APA
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., & Hamaguchi, M. (2009). Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling. International Journal of Oncology, 35, 309-314. https://doi.org/10.3892/ijo_00000341
MLA
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., Hamaguchi, M."Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling". International Journal of Oncology 35.2 (2009): 309-314.
Chicago
Yuan, H., Ito, S., Senga, T., Hyodo, T., Kiyono, T., Kikkawa, F., Hamaguchi, M."Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling". International Journal of Oncology 35, no. 2 (2009): 309-314. https://doi.org/10.3892/ijo_00000341
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