Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy

  • Authors:
    • Anastasios Sofiadis
    • Edneia Tani
    • Theodoros Foukakis
    • Petra Kjellman
    • Lambert Skoog
    • Anders Höög
    • Göran Wallin
    • Jan Zedenius
    • Catharina Larsson
  • View Affiliations

  • Published online on: August 1, 2009     https://doi.org/10.3892/ijo_00000348
  • Pages: 369-374
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fine needle aspiration biopsy (FNAB) is the preferred technique for the initial diagnostic evaluation of thyroid lesions, which nevertheless poses a diagnostic challenge for all clinicians involved. The latter necessitates the use of molecular markers on thyroid cytology. MIB-1 is a molecular marker already used in the cytological evaluation of various tumors. In this study, we assessed whether MIB-1 proliferation index adds diagnostic information to the conventional cytological analysis of thyroid nodules and prognostic information in thyroid cancers. MIB-1 index for various thyroid lesions was retrospectively reviewed in a series of 504 patients. Furthermore, the prognostic value of MIB-1 index was investigated for 183 of the patients with papillary thyroid cancer (PTC). MIB-1 index was significantly higher in anaplastic thyroid cancer (ATC) compared to other tumor types (p<0.01). No significant difference in MIB-1 index was observed between thyroid adenomas and follicular carcinomas. In PTC, MIB-1 index equal to or >4% was found to be an independent factor significantly associated with higher risk of distant metastasis and disease-related mortality (p<0.05). Conclusively, this study shows that preoperative MIB-1 index assessment in FNAB of thyroid nodules offers little diagnostic information as far as follicular tumors are concerned. In cases of PTC, though, MIB-1 may serve as a prognostic indicator of disease spreading and poor survival and hence influence the planning of the overall treatment scheme.

Related Articles

Journal Cover

August 2009
Volume 35 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sofiadis A, Tani E, Foukakis T, Kjellman P, Skoog L, Höög A, Wallin G, Zedenius J and Larsson C: Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy. Int J Oncol 35: 369-374, 2009
APA
Sofiadis, A., Tani, E., Foukakis, T., Kjellman, P., Skoog, L., Höög, A. ... Larsson, C. (2009). Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy. International Journal of Oncology, 35, 369-374. https://doi.org/10.3892/ijo_00000348
MLA
Sofiadis, A., Tani, E., Foukakis, T., Kjellman, P., Skoog, L., Höög, A., Wallin, G., Zedenius, J., Larsson, C."Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy". International Journal of Oncology 35.2 (2009): 369-374.
Chicago
Sofiadis, A., Tani, E., Foukakis, T., Kjellman, P., Skoog, L., Höög, A., Wallin, G., Zedenius, J., Larsson, C."Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy". International Journal of Oncology 35, no. 2 (2009): 369-374. https://doi.org/10.3892/ijo_00000348