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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2009 Volume 35 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 35 Issue 3

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Article

Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization

  • Authors:
    • C. M. Haaland
    • C. M. Heaphy
    • K. S. Butler
    • E. G. Fischer
    • J. K. Griffith
    • M. Bisoffi

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, USA
  • Pages: 537-546
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijo_00000365
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Abstract

Field cancerization denotes the occurrence of aberrant cells in tumor adjacent histologically normal tissues (TAHN). To characterize field cancerization in prostate cancer, we used RNA from paired patient tumor and TAHN tissues excised at 1 cm from the tumor margin and subjected them to microarray expression analysis comparative to RNA from normal cancer-free prostatic tissues. Eleven novel transcripts were significantly up-regulated in TAHN tissues and also in tumors. Expression of early growth response protein 1, tristetraprolin, testican, and fatty acid synthase, mutually up-regulated at different levels in tumors and TAHN tissues was confirmed by quantitative reverse transcriptase PCR in the experimental and in an independent validation set. This study offers proof of expressional changes in field cancerized prostatic TAHN tissues at defined distances from tumor margins. Markers of field cancerized prostatic tissues could be early diagnostic indicators in biopsies after abnormal prostate-specific antigen and digital rectal examination and independent of cancerous histology and/or early targets for chemo-preventive intervention in pre-malignant disease.

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Copy and paste a formatted citation
Spandidos Publications style
Haaland CM, Heaphy CM, Butler KS, Fischer EG, Griffith JK and Bisoffi M: Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization. Int J Oncol 35: 537-546, 2009.
APA
Haaland, C.M., Heaphy, C.M., Butler, K.S., Fischer, E.G., Griffith, J.K., & Bisoffi, M. (2009). Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization. International Journal of Oncology, 35, 537-546. https://doi.org/10.3892/ijo_00000365
MLA
Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K., Bisoffi, M."Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization". International Journal of Oncology 35.3 (2009): 537-546.
Chicago
Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K., Bisoffi, M."Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization". International Journal of Oncology 35, no. 3 (2009): 537-546. https://doi.org/10.3892/ijo_00000365
Copy and paste a formatted citation
x
Spandidos Publications style
Haaland CM, Heaphy CM, Butler KS, Fischer EG, Griffith JK and Bisoffi M: Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization. Int J Oncol 35: 537-546, 2009.
APA
Haaland, C.M., Heaphy, C.M., Butler, K.S., Fischer, E.G., Griffith, J.K., & Bisoffi, M. (2009). Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization. International Journal of Oncology, 35, 537-546. https://doi.org/10.3892/ijo_00000365
MLA
Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K., Bisoffi, M."Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization". International Journal of Oncology 35.3 (2009): 537-546.
Chicago
Haaland, C. M., Heaphy, C. M., Butler, K. S., Fischer, E. G., Griffith, J. K., Bisoffi, M."Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization". International Journal of Oncology 35, no. 3 (2009): 537-546. https://doi.org/10.3892/ijo_00000365
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