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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2009 Volume 35 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 35 Issue 6

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Article

Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy

  • Authors:
    • Shinji Amano
    • Shaoyi Li
    • Chunyu Gu
    • Yun Gao
    • Shinichiro Koizumi
    • Seiji Yamamoto
    • Susumu Terakawa
    • Hiroki Namba

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu 431-3192, Japan
  • Pages: 1265-1270
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijo_00000443
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Abstract

In our previous study, we successfully treated an established C6 brain tumor using neural stem cells transduced with the herpes simplex virus-thymidine kinase gene (HSVtk) and ganciclovir in the rat. In the present study, we investigated the use of mesenchymal stem cells (MSCs), obtained from adult rats and transduced with HSVtk (MSCtk cells), instead of neural stem cells because MSCs are much easier to obtain from the adult subjects. Those cells were used for in vitro co-culture study and in vivo co-implantation study with C6 rat glioma cells to examine bystander tumoricidal effect, which revealed a sufficient bystander effect and only 1/32 MSCtk cells were needed for complete tumor eradication. In vitro bystander effect was also observed in a real-time fashion using a culture microscope and it was shown that only tumor cells that had contact with MSCtk cells died. In vivo treatment study of an established C6 brain tumor with an intratumoral injection of MSCtk cells followed by systemic ganciclovir administration demonstrated a significant reduction of the tumor size and a significant survival prolongation. The treatment strategy using MSCtk and ganciclovir (MSCtk therapy) is more feasible and practical for clinical application than the method using neural stem cells.

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Copy and paste a formatted citation
Spandidos Publications style
Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S and Namba H: Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy. Int J Oncol 35: 1265-1270, 2009.
APA
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S. ... Namba, H. (2009). Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy. International Journal of Oncology, 35, 1265-1270. https://doi.org/10.3892/ijo_00000443
MLA
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S., Terakawa, S., Namba, H."Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy". International Journal of Oncology 35.6 (2009): 1265-1270.
Chicago
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S., Terakawa, S., Namba, H."Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy". International Journal of Oncology 35, no. 6 (2009): 1265-1270. https://doi.org/10.3892/ijo_00000443
Copy and paste a formatted citation
x
Spandidos Publications style
Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S and Namba H: Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy. Int J Oncol 35: 1265-1270, 2009.
APA
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S. ... Namba, H. (2009). Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy. International Journal of Oncology, 35, 1265-1270. https://doi.org/10.3892/ijo_00000443
MLA
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S., Terakawa, S., Namba, H."Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy". International Journal of Oncology 35.6 (2009): 1265-1270.
Chicago
Amano, S., Li, S., Gu, C., Gao, Y., Koizumi, S., Yamamoto, S., Terakawa, S., Namba, H."Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy". International Journal of Oncology 35, no. 6 (2009): 1265-1270. https://doi.org/10.3892/ijo_00000443
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