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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2009 Volume 35 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 35 Issue 6

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Article

Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism

  • Authors:
    • Qian Xu
    • Yuan Yuan
    • Li-Ping Sun
    • Yue-Hua Gong
    • Ying Xu
    • Xiu-Wen Yu
    • Nan-Nan Dong
    • G. David Lin
    • Paul N. Smith
    • Rachel W. Li

  • View Affiliations / Copyright

    Affiliations: Cancer Control Laboratory of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, P.R. China
  • Pages: 1313-1320
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijo_00000449
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Abstract

Identifying the genetic variants that alter MUC1 protein expression may further our understanding of the risk for development of gastric cancer (GC). We used PCR-SSPs to identify the genotype of MUC1 A/G polymorphism at its 568 site of exon 2 and immunohistochemistry to detect MUC1 protein expression in GC patients and non-cancer subjects and analyzed the association between this polymorphism and MUC1 protein expression. We found that the frequency of AA genotype was significantly high in the GC patients and the risk for GC in AA genotype carriers increased 1.81-fold. Moreover, we found a significant underexpression of MUC1 protein in GC as compared to non-cancer subjects, which was negatively correlated to AA genotype of MUC1 (r=−0.1790, P=0.004). Furthermore, this study provides a possible mechanistic insight that the MUC1 A/G polymorphism at its 568 site disrupts the physiological functions of MUC1 which is important to the physiological protection of gastric mucosa. Thus we have provided evidence that may identify the MUC1 A/G polymorphism at 568 site, as a potential genetic factor which leads to an increase in susceptibility for GC through alteration of MUC1 gene and MUC1 expression in the population that carry the A allele.

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Copy and paste a formatted citation
Spandidos Publications style
Xu Q, Yuan Y, Sun L, Gong Y, Xu Y, Yu X, Dong N, Lin GD, Smith PN, Li RW, Li RW, et al: Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol 35: 1313-1320, 2009.
APA
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X. ... Li, R.W. (2009). Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. International Journal of Oncology, 35, 1313-1320. https://doi.org/10.3892/ijo_00000449
MLA
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X., Dong, N., Lin, G. D., Smith, P. N., Li, R. W."Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism". International Journal of Oncology 35.6 (2009): 1313-1320.
Chicago
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X., Dong, N., Lin, G. D., Smith, P. N., Li, R. W."Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism". International Journal of Oncology 35, no. 6 (2009): 1313-1320. https://doi.org/10.3892/ijo_00000449
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Q, Yuan Y, Sun L, Gong Y, Xu Y, Yu X, Dong N, Lin GD, Smith PN, Li RW, Li RW, et al: Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. Int J Oncol 35: 1313-1320, 2009.
APA
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X. ... Li, R.W. (2009). Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism. International Journal of Oncology, 35, 1313-1320. https://doi.org/10.3892/ijo_00000449
MLA
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X., Dong, N., Lin, G. D., Smith, P. N., Li, R. W."Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism". International Journal of Oncology 35.6 (2009): 1313-1320.
Chicago
Xu, Q., Yuan, Y., Sun, L., Gong, Y., Xu, Y., Yu, X., Dong, N., Lin, G. D., Smith, P. N., Li, R. W."Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism". International Journal of Oncology 35, no. 6 (2009): 1313-1320. https://doi.org/10.3892/ijo_00000449
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