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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2009 Volume 35 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 35 Issue 6

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Article Open Access

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

  • Authors:
    • Matilda Rentoft
    • Göran Laurell
    • Philip John Coates
    • Björn Sjöström
    • Karin Nylander

  • View Affiliations / Copyright

    Affiliations: Department of Medical Biosciences/Pathology, Umeå University, SE-901 85 Umeå, Sweden. matilda.rentoft@medbio.umu.se
  • Pages: 1321-1330
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijo_00000450
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Abstract

A subgroup of patients with squamous cell carcinoma of the head and neck (SCCHN) comprise young persons under the age of 40, who have not been heavily exposed to the classical risk factors, smoking and alcohol. The number of SCCHN in young adults, particularly tongue tumours, is increasing in several parts of the world. Here we employed a novel gene expression array methodology specifically developed for analysis of degraded RNA and investigated the expression of 502 cancer-related genes in archival paraffin-embedded SCCHN of the tongue from young (≤40) and elderly patients (≥50). Genes detected as de-regulated in tumours compared to non-malignant controls were in concordance with results from earlier studies of fresh frozen material. No genes were detected as significantly differentially expressed between young and old patients suggesting that the overall pathobiology of SCCHN is similar in young and old. Unsupervised clustering divided tumours into three groups, irrespective of age, where several differentially expressed DNA repair genes were a prominent separation factor. High levels of DNA repair genes associated with impaired therapeutic response to radiation, suggesting that DNA repair genes play a role in clinical outcome after radiotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Rentoft M, Laurell G, Coates PJ, Sjöström B and Nylander K: Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes. Int J Oncol 35: 1321-1330, 2009.
APA
Rentoft, M., Laurell, G., Coates, P.J., Sjöström, B., & Nylander, K. (2009). Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes. International Journal of Oncology, 35, 1321-1330. https://doi.org/10.3892/ijo_00000450
MLA
Rentoft, M., Laurell, G., Coates, P. J., Sjöström, B., Nylander, K."Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes". International Journal of Oncology 35.6 (2009): 1321-1330.
Chicago
Rentoft, M., Laurell, G., Coates, P. J., Sjöström, B., Nylander, K."Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes". International Journal of Oncology 35, no. 6 (2009): 1321-1330. https://doi.org/10.3892/ijo_00000450
Copy and paste a formatted citation
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Spandidos Publications style
Rentoft M, Laurell G, Coates PJ, Sjöström B and Nylander K: Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes. Int J Oncol 35: 1321-1330, 2009.
APA
Rentoft, M., Laurell, G., Coates, P.J., Sjöström, B., & Nylander, K. (2009). Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes. International Journal of Oncology, 35, 1321-1330. https://doi.org/10.3892/ijo_00000450
MLA
Rentoft, M., Laurell, G., Coates, P. J., Sjöström, B., Nylander, K."Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes". International Journal of Oncology 35.6 (2009): 1321-1330.
Chicago
Rentoft, M., Laurell, G., Coates, P. J., Sjöström, B., Nylander, K."Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes". International Journal of Oncology 35, no. 6 (2009): 1321-1330. https://doi.org/10.3892/ijo_00000450
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