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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2009 Volume 35 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 35 Issue 6

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Article

MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells

  • Authors:
    • Sangsu Shin
    • Eun-Mee Lee
    • Hwa Jun Cha
    • Seunghee Bae
    • Jin Hyuk Jung
    • Sun-Mi Lee
    • Youngmin Yoon
    • Hyunjin Lee
    • Sumi Kim
    • Hyunsook Kim
    • Su-Jae Lee
    • In-Chul Park
    • Young-Woo Jin
    • Sungkwan An

  • View Affiliations / Copyright

    Affiliations: Functional Genoproteome Research Centre, Konkuk University, Seoul 143-701, Korea
  • Pages: 1343-1352
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijo_00000452
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Abstract

MicroRNAs (miRNAs) are important post-transcriptional regulators involved in many biological processes. We investigated the expression profiles of miRNAs affected by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), and p53 in the human colon cancer cell line, HCT116 (wt-p53) and its derivative, HCT116 (null-p53). In a microarray assay, 144 of 275 human miRNAs showed several-fold changes in transcription. Most of these miRNAs were strongly affected by SAHA, and their expression profiles varied depending on the presence of p53. Thirty-one miRNAs showing the greatest expression changes were selected for target prediction, and genes related to apoptosis (102), cell cycle (38), and differentiation (102) were predicted. Each miRNA had many target genes, and several genes also were targeted by many miRNAs. Putative p53 upstream binding sites for the miRNAs were determined, and most sites scored >85%, suggesting a high probability of binding. In conclusion, we identified several miRNAs whose expression was affected by both SAHA and p53. Many of the miRNAs showed dramatic changes and were predicted to target many mRNAs. Further studies will be needed to verify these predictions.

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Copy and paste a formatted citation
Spandidos Publications style
Shin S, Lee E, Cha HJ, Bae S, Jung JH, Lee S, Yoon Y, Lee H, Kim S, Kim H, Kim H, et al: MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells. Int J Oncol 35: 1343-1352, 2009.
APA
Shin, S., Lee, E., Cha, H.J., Bae, S., Jung, J.H., Lee, S. ... An, S. (2009). MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells. International Journal of Oncology, 35, 1343-1352. https://doi.org/10.3892/ijo_00000452
MLA
Shin, S., Lee, E., Cha, H. J., Bae, S., Jung, J. H., Lee, S., Yoon, Y., Lee, H., Kim, S., Kim, H., Lee, S., Park, I., Jin, Y., An, S."MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells". International Journal of Oncology 35.6 (2009): 1343-1352.
Chicago
Shin, S., Lee, E., Cha, H. J., Bae, S., Jung, J. H., Lee, S., Yoon, Y., Lee, H., Kim, S., Kim, H., Lee, S., Park, I., Jin, Y., An, S."MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells". International Journal of Oncology 35, no. 6 (2009): 1343-1352. https://doi.org/10.3892/ijo_00000452
Copy and paste a formatted citation
x
Spandidos Publications style
Shin S, Lee E, Cha HJ, Bae S, Jung JH, Lee S, Yoon Y, Lee H, Kim S, Kim H, Kim H, et al: MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells. Int J Oncol 35: 1343-1352, 2009.
APA
Shin, S., Lee, E., Cha, H.J., Bae, S., Jung, J.H., Lee, S. ... An, S. (2009). MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells. International Journal of Oncology, 35, 1343-1352. https://doi.org/10.3892/ijo_00000452
MLA
Shin, S., Lee, E., Cha, H. J., Bae, S., Jung, J. H., Lee, S., Yoon, Y., Lee, H., Kim, S., Kim, H., Lee, S., Park, I., Jin, Y., An, S."MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells". International Journal of Oncology 35.6 (2009): 1343-1352.
Chicago
Shin, S., Lee, E., Cha, H. J., Bae, S., Jung, J. H., Lee, S., Yoon, Y., Lee, H., Kim, S., Kim, H., Lee, S., Park, I., Jin, Y., An, S."MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells". International Journal of Oncology 35, no. 6 (2009): 1343-1352. https://doi.org/10.3892/ijo_00000452
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