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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2009 Volume 35 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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December 2009 Volume 35 Issue 6

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Article Open Access

Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin

  • Authors:
    • Hiroshi Hamajima
    • Iwata Ozaki
    • Hao Zhang
    • Shinji Iwane
    • Yasunori Kawaguchi
    • Yuichiro Eguchi
    • Sachiko Matsuhashi
    • Toshihiko Mizuta
    • Koichi Matsuzaki
    • Kazuma Fujimoto
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Saga Medical School, Saga University, Saga 849-8501, Japan
  • Pages: 1441-1447
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijo_00000463
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Abstract

Integrins, heterodimeric receptors for the extracellular matrix, are known to modulate transforming growth factor-β1 (TGF-β1)-mediated cell behavior. However, the interplay between β1-integrin and Smad signaling, regulated by TGF-β1, is not clearly understood. This study focuses on the alterations of the regulatory Smads (R-Smads) by TGF-β1 in β1-integrin-transfected HepG2 cells. The phosphorylation at the C-terminal site of R-Smads by TGF-β1 was impaired in the β1-integrin-transfected cells. However, the R-Smads were constitutively phosphorylated at the linker region in a MAP kinase-dependent manner. Furthermore, the expression of a mutant Smad3, that lacks the phosphorylation sites in the linker region, restored the TGF-β1-induced Smad transcriptional activity. These results suggest that β1-integrin impairs the TGF-β1-mediated signals through the altered phosphorylation of the R-Smads.

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Copy and paste a formatted citation
Spandidos Publications style
Hamajima H, Ozaki I, Zhang H, Iwane S, Kawaguchi Y, Eguchi Y, Matsuhashi S, Mizuta T, Matsuzaki K, Fujimoto K, Fujimoto K, et al: Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin. Int J Oncol 35: 1441-1447, 2009.
APA
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y. ... Fujimoto, K. (2009). Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin. International Journal of Oncology, 35, 1441-1447. https://doi.org/10.3892/ijo_00000463
MLA
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y., Matsuhashi, S., Mizuta, T., Matsuzaki, K., Fujimoto, K."Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin". International Journal of Oncology 35.6 (2009): 1441-1447.
Chicago
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y., Matsuhashi, S., Mizuta, T., Matsuzaki, K., Fujimoto, K."Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin". International Journal of Oncology 35, no. 6 (2009): 1441-1447. https://doi.org/10.3892/ijo_00000463
Copy and paste a formatted citation
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Spandidos Publications style
Hamajima H, Ozaki I, Zhang H, Iwane S, Kawaguchi Y, Eguchi Y, Matsuhashi S, Mizuta T, Matsuzaki K, Fujimoto K, Fujimoto K, et al: Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin. Int J Oncol 35: 1441-1447, 2009.
APA
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y. ... Fujimoto, K. (2009). Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin. International Journal of Oncology, 35, 1441-1447. https://doi.org/10.3892/ijo_00000463
MLA
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y., Matsuhashi, S., Mizuta, T., Matsuzaki, K., Fujimoto, K."Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin". International Journal of Oncology 35.6 (2009): 1441-1447.
Chicago
Hamajima, H., Ozaki, I., Zhang, H., Iwane, S., Kawaguchi, Y., Eguchi, Y., Matsuhashi, S., Mizuta, T., Matsuzaki, K., Fujimoto, K."Modulation of the transforming growth factor-β1-induced Smad phosphorylation by the extracellular matrix receptor β1-integrin". International Journal of Oncology 35, no. 6 (2009): 1441-1447. https://doi.org/10.3892/ijo_00000463
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