The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box

  • Authors:
    • Vandana S. Dole
    • Hans Smola
    • Steven Dooley
    • Harun M. Said
    • Monika Oldak
    • Herbert J. Pfister
    • Sigrun Smola
  • View Affiliations

  • Published online on: December 1, 2009     https://doi.org/10.3892/ijo_00000468
  • Pages: 1493-1498
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Abstract

DNA tumorviruses like adenoviruses (AdV) or human papillomaviruses (HPV) have adopted various strategies to interfere with antiproliferative transforming growth factor-β (TGF-β) signalling. Here we report that the AdV E1A oncoprotein is sufficient to induce Smad7 expression, an inhibitor of TGF-β signalling. E1A but not HPV oncoproteins activated the Smad7 promoter. A promoter proximal E-box was crucial for E1A-mediated transcriptional activity. E1A but not HPV oncoproteins induced specific binding activity at this E-box, which was identified as upstream stimulatory factor. In conclusion, these results unravel a novel mechanism of how the AdV E1A oncoprotein induces a cellular inhibitor of TGF-β signalling.

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December 2009
Volume 35 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Dole VS, Smola H, Dooley S, Said HM, Oldak M, Pfister HJ and Smola S: The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box. Int J Oncol 35: 1493-1498, 2009
APA
Dole, V.S., Smola, H., Dooley, S., Said, H.M., Oldak, M., Pfister, H.J., & Smola, S. (2009). The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box. International Journal of Oncology, 35, 1493-1498. https://doi.org/10.3892/ijo_00000468
MLA
Dole, V. S., Smola, H., Dooley, S., Said, H. M., Oldak, M., Pfister, H. J., Smola, S."The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box". International Journal of Oncology 35.6 (2009): 1493-1498.
Chicago
Dole, V. S., Smola, H., Dooley, S., Said, H. M., Oldak, M., Pfister, H. J., Smola, S."The adenoviral E1A oncoprotein activates the Smad7 promoter: Requirement of a functional E-box". International Journal of Oncology 35, no. 6 (2009): 1493-1498. https://doi.org/10.3892/ijo_00000468