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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2010 Volume 36 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 36 Issue 1

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Review

Angiogenesis: An update and potential drug approaches (Review)

  • Authors:
    • Maen Abdelrahim
    • Santhi Konduri
    • Md. Riyaz Basha
    • Philip A. Philip
    • Cheryl H. Baker

  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, FL 32806, USA. maen.abdelrahim@orlandohealth.com
  • Pages: 5-18
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ijo_00000470
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Abstract

The therapeutic potential of targeting tumor endothelium and vascular supply is now widely recognized to treat different diseases. One such disease is cancer; where endothelial cells are actively proliferating to support the tumor growth. Solid tumors cannot grow beyond the size of a few millimeters without inducing the proliferation of endothelium and formation of new blood vessels. Hence it is crucial to search for new agents that selectively block tumor blood supply. These include anti-angiogenic molecules, vascular disrupting agents or endothelial disrupting agents. The anti-angiogenic molecules such as monoclonal antibodies and tyrosine kinase inhibitors disrupt endothelial cell survival mechanisms and new blood vessel formation, and vascular disrupting agents for instance ligand-directed and small molecules can be used to disrupt the already existing abnormal vasculature that support tumors by targeting their dysmorphic endothelial cells. The recent advances in this area of research have identified a variety of investigational agents which are currently in clinical development at various stages and some of these candidates are already approved in cancer treatment. This report will review some of the recent developments and most significant advances in this field and outline future challenges and directions.

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Copy and paste a formatted citation
Spandidos Publications style
Abdelrahim M, Konduri S, Riyaz Basha M, Philip PA and Baker CH: Angiogenesis: An update and potential drug approaches (Review). Int J Oncol 36: 5-18, 2010.
APA
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P.A., & Baker, C.H. (2010). Angiogenesis: An update and potential drug approaches (Review). International Journal of Oncology, 36, 5-18. https://doi.org/10.3892/ijo_00000470
MLA
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P. A., Baker, C. H."Angiogenesis: An update and potential drug approaches (Review)". International Journal of Oncology 36.1 (2010): 5-18.
Chicago
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P. A., Baker, C. H."Angiogenesis: An update and potential drug approaches (Review)". International Journal of Oncology 36, no. 1 (2010): 5-18. https://doi.org/10.3892/ijo_00000470
Copy and paste a formatted citation
x
Spandidos Publications style
Abdelrahim M, Konduri S, Riyaz Basha M, Philip PA and Baker CH: Angiogenesis: An update and potential drug approaches (Review). Int J Oncol 36: 5-18, 2010.
APA
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P.A., & Baker, C.H. (2010). Angiogenesis: An update and potential drug approaches (Review). International Journal of Oncology, 36, 5-18. https://doi.org/10.3892/ijo_00000470
MLA
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P. A., Baker, C. H."Angiogenesis: An update and potential drug approaches (Review)". International Journal of Oncology 36.1 (2010): 5-18.
Chicago
Abdelrahim, M., Konduri, S., Riyaz Basha, M., Philip, P. A., Baker, C. H."Angiogenesis: An update and potential drug approaches (Review)". International Journal of Oncology 36, no. 1 (2010): 5-18. https://doi.org/10.3892/ijo_00000470
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