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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2010 Volume 36 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 36 Issue 1

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Article Open Access

Epigenetic silencing of RELN in gastric cancer

  • Authors:
    • Osamu Dohi
    • Hisashi Takada
    • Naoki Wakabayashi
    • Kohichiroh Yasui
    • Chouhei Sakakura
    • Shoji Mitsufuji
    • Yuji Naito
    • Masafumi Taniwaki
    • Toshikazu Yoshikawa
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
  • Pages: 85-92
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/ijo_00000478
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Abstract

RELN (Reelin) is an extracellular glycoprotein that plays a critical role in neuronal migration. Here we show that the RELN gene is frequently silenced in gastric cancers (GCs) by aberrant promoter hypermethylation. Although RELN was strongly expressed in non-tumor gastric epithelia, its expression was weak, or absent, in GC cell lines and primary GC tumors. Absence of RELN expression significantly correlated with a more advanced stage of GC. Methylation of the RELN promoter was frequently found in GC cell lines and in primary GC tumors. These findings suggest that disruption of the RELN pathway may be involved in gastric carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Dohi O, Takada H, Wakabayashi N, Yasui K, Sakakura C, Mitsufuji S, Naito Y, Taniwaki M and Yoshikawa T: Epigenetic silencing of RELN in gastric cancer. Int J Oncol 36: 85-92, 2010.
APA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S. ... Yoshikawa, T. (2010). Epigenetic silencing of RELN in gastric cancer. International Journal of Oncology, 36, 85-92. https://doi.org/10.3892/ijo_00000478
MLA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36.1 (2010): 85-92.
Chicago
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36, no. 1 (2010): 85-92. https://doi.org/10.3892/ijo_00000478
Copy and paste a formatted citation
x
Spandidos Publications style
Dohi O, Takada H, Wakabayashi N, Yasui K, Sakakura C, Mitsufuji S, Naito Y, Taniwaki M and Yoshikawa T: Epigenetic silencing of RELN in gastric cancer. Int J Oncol 36: 85-92, 2010.
APA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S. ... Yoshikawa, T. (2010). Epigenetic silencing of RELN in gastric cancer. International Journal of Oncology, 36, 85-92. https://doi.org/10.3892/ijo_00000478
MLA
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36.1 (2010): 85-92.
Chicago
Dohi, O., Takada, H., Wakabayashi, N., Yasui, K., Sakakura, C., Mitsufuji, S., Naito, Y., Taniwaki, M., Yoshikawa, T."Epigenetic silencing of RELN in gastric cancer". International Journal of Oncology 36, no. 1 (2010): 85-92. https://doi.org/10.3892/ijo_00000478
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