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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2010 Volume 36 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 36 Issue 3

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Article Open Access

Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation

  • Authors:
    • Masanori Nakashima
    • Seiji Adachi
    • Ichiro Yasuda
    • Takahiro Yamauchi
    • Osamu Kozawa
    • Hisataka Moriwaki

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
  • Pages: 585-592
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijo_00000533
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Abstract

It has been reported that Rho and Rho-kinase are involved in actin cytoskeleton organization and associated with carcinogenesis and progression of human cancers. However, the mechanism how the Rho/Rho-kinase pathway is involved in cell cycle progression has not been precisely characterized. In this study, we investigated the role of Rho-kinase in epidermal growth factor (EGF) signaling in SW480 colon cancer cells. We found that Y27632, a Rho-kinase inhibitor, dose-dependently induced cell proliferation in these cells. The blockade of EGF stimulation utilizing anti-EGF receptor neutralizing antibodies significantly suppressed cell growth, suggesting that EGF stimulation plays an important role in cell proliferation in SW480 cells. We also found that EGF induced Rho-kinase activation. Interestingly, EGF-induced phosphorylation of both Akt and glycogen synthase kinase-3β (GSK-3β), but not p44/p42 mitogen-activated protein (MAP) kinase, were dose-dependently enhanced when the cells were pretreated with Y27632 or fasudil, another Rho-kinase inhibitor. Moreover, whereas EGF increased the phosphorylation of retinoblastoma tumor suppressor protein as well as cyclin D1 protein expression level, pretreatment with Y27632 accelerated them. Taken together, our results suggest that Rho-kinase regulates negatively EGF-induced cell proliferation upstream of Akt/GSK-3β in colon cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kozawa O and Moriwaki H: Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation. Int J Oncol 36: 585-592, 2010.
APA
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., & Moriwaki, H. (2010). Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation. International Journal of Oncology, 36, 585-592. https://doi.org/10.3892/ijo_00000533
MLA
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., Moriwaki, H."Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation". International Journal of Oncology 36.3 (2010): 585-592.
Chicago
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., Moriwaki, H."Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation". International Journal of Oncology 36, no. 3 (2010): 585-592. https://doi.org/10.3892/ijo_00000533
Copy and paste a formatted citation
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Spandidos Publications style
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kozawa O and Moriwaki H: Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation. Int J Oncol 36: 585-592, 2010.
APA
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., & Moriwaki, H. (2010). Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation. International Journal of Oncology, 36, 585-592. https://doi.org/10.3892/ijo_00000533
MLA
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., Moriwaki, H."Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation". International Journal of Oncology 36.3 (2010): 585-592.
Chicago
Nakashima, M., Adachi, S., Yasuda, I., Yamauchi, T., Kozawa, O., Moriwaki, H."Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation". International Journal of Oncology 36, no. 3 (2010): 585-592. https://doi.org/10.3892/ijo_00000533
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