Upregulation of Notch pathway molecules in oral squamous cell carcinoma

  • Authors:
    • Hiroshi Hijioka
    • Takao Setoguchi
    • Akihiko Miyawaki
    • Hui Gao
    • Takayuki Ishida
    • Setsuro Komiya
    • Norifumi Nakamura
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/ijo_00000558
  • Pages: 817-822
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Abstract

The constitutive activation of the Notch pathway has been demonstrated in various types of malignancies. However, it remains unclear how the Notch pathway is involved in the pathogenesis of oral squamous cell carcinoma (OSCC). We investigated the expression of Notch pathway molecules in OSCC cell lines and biopsy specimens and examined the effect of Notch pathway inhibition. Reverse transcription-polymerase chain reaction revealed upregulation of Notch1, Notch2, Jagged1, HES1 and HEY1 in both OSCC cell lines and biopsy specimens. Immunohistochemical examination showed that the Notch intracellular domain accumulates in the nucleus of cells in OSCC cell lines and biopsy specimens. In addition, Jagged1 is expressed in the cytoplasm of cells in OSCC cell lines and biopsy specimens. Furthermore, Notch pathway inhibition using a γ-secretase inhibitor prevented the growth of OSCC in vitro. These findings suggest that inhibition of the Notch pathway suppresses OSCC growth and may be a useful approach for the treatment of patients with OSCC.

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April 2010
Volume 36 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hijioka H, Setoguchi T, Miyawaki A, Gao H, Ishida T, Komiya S and Nakamura N: Upregulation of Notch pathway molecules in oral squamous cell carcinoma. Int J Oncol 36: 817-822, 2010
APA
Hijioka, H., Setoguchi, T., Miyawaki, A., Gao, H., Ishida, T., Komiya, S., & Nakamura, N. (2010). Upregulation of Notch pathway molecules in oral squamous cell carcinoma. International Journal of Oncology, 36, 817-822. https://doi.org/10.3892/ijo_00000558
MLA
Hijioka, H., Setoguchi, T., Miyawaki, A., Gao, H., Ishida, T., Komiya, S., Nakamura, N."Upregulation of Notch pathway molecules in oral squamous cell carcinoma". International Journal of Oncology 36.4 (2010): 817-822.
Chicago
Hijioka, H., Setoguchi, T., Miyawaki, A., Gao, H., Ishida, T., Komiya, S., Nakamura, N."Upregulation of Notch pathway molecules in oral squamous cell carcinoma". International Journal of Oncology 36, no. 4 (2010): 817-822. https://doi.org/10.3892/ijo_00000558