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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2010 Volume 36 Issue 4

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Lovisa Göstring, Ming Tsuey Chew, Anna Orlova, Ingmarie Höidén-Guthenberg, Anders Wennborg, Jörgen Carlsson, Fredrik Y. Frejd
Pages: 757-763
Published online on: 01 April 2010

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MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues

Keisuke Okudaira, Sanjay Kakar, Lisa Cun, Ester Choi, Rina Wu DeCamillis, Soichiro Miura, Marvin H. Sleisenger, Young S. Kim, Gouren Deng
Pages: 765-775
Published online on: 01 April 2010

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Article

Targeted photodynamic therapy for prostate cancer: Inducing apoptosis via activation of the caspase-8/-3 cascade pathway

Tiancheng Liu, Lisa Y. Wu, Joseph K. Choi, Clifford E. Berkman
Pages: 777-784
Published online on: 01 April 2010

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Article

HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo

Paolo Fiorenzo, Maria Patrizia Mongiardi, Diletta Dimitri, Mauro Cozzolino, Alberto Ferri, Nicola Montano, Gianluca Trevisi, Giulio Maira, Luca Battistini, Maria Laura Falchetti, Andrea Levi, Roberto Pallini
Pages: 785-791
Published online on: 01 April 2010

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Article

Tumor-derived trypsin enhances proliferation of intrahepatic cholangiocarcinoma cells by activating protease-activated receptor-2

Shin-Ichi Nakanuma, Hidehiro Tajima, Kouichi Okamoto, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Tetsuo Ohta, Tomohiko Wakayama, Shoichi Iseki, Shin-Ichi Harada
Pages: 793-800
Published online on: 01 April 2010

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Article

Photoactivation of 9-hydroxypheophorbide α triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells

Peijie He, Jin-Chul Ahn, Jang-In Shin, Phil-Sang Chung
Pages: 801-808
Published online on: 01 April 2010

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Article

Radiation-inducible silencing of uPA and uPAR in vitro and in vivo in meningioma

Venkateswara Rao Gogineni, Arun Kumar Nalla, Reshu Gupta, Bharathi Gorantla, Meena Gujrati, Dzung H. Dinh, Jasti S. Rao
Pages: 809-816
Published online on: 01 April 2010

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Article

Upregulation of Notch pathway molecules in oral squamous cell carcinoma

Hiroshi Hijioka, Takao Setoguchi, Akihiko Miyawaki, Hui Gao, Takayuki Ishida, Setsuro Komiya, Norifumi Nakamura
Pages: 817-822
Published online on: 01 April 2010

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Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo

Satoshi Takenaka, Norifumi Naka, Nobuhito Araki, Nobuyuki Hashimoto, Takafumi Ueda, Kiyoko Yoshioka, Hideki Yoshikawa, Kazuyuki Itoh
Pages: 823-831
Published online on: 01 April 2010

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Article

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP

Ondrej Tolde, Daniel Rösel, Claudia T. Mierke, Daniela Panková, Petr Folk, Pavel Vesely, Jan Brábek
Pages: 833-839
Published online on: 01 April 2010

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Article

Regulatory T cell depletion enhances tumor specific CD8 T-cell responses, elicited by tumor antigen NY-ESO-1b in hepatocellular carcinoma patients, in vitro

Heng-Hui Zhang, Ming-Hui Mei, Ran Fei, Wei-Jia Liao, Xue-Yan Wang, Li-Ling Qin, Jiang-Hua Wang, Lai Wei, Hong-Song Chen
Pages: 841-848
Published online on: 01 April 2010

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Article

Development of an oral cancer recurrence mouse model after surgical resection

Andreas Behren, York Kamenisch, Sabrina Muehlen, Christa Flechtenmacher, Uwe Haberkorn, Hermann Hilber, Jeffrey N. Myers, Zazie Bergmann, Peter Karl Plinkert, Christian Simon
Pages: 849-855
Published online on: 01 April 2010

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Article

Carvedilol in glioma treatment alone and with imatinib in vitro

Mine Erguven, Nuray Yazihan, Esin Aktas, Akin Sabanci, Chiang J. Li, Gulperi Oktem, Ayhan Bilir
Pages: 857-866
Published online on: 01 April 2010

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Article

The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells

Soo-A Kim, Seong-Min Kwon, Jung-Hoon Yoon, Sang-Gun Ahn
Pages: 867-872
Published online on: 01 April 2010

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Targeting the cell cycle and the PI3K pathway: A possible universal strategy to reactivate innate tumor suppressor programmes in cancer cells

Thérèse David-Pfeuty, Michel Legraverend, Odile Ludwig, David S. Grierson
Pages: 873-881
Published online on: 01 April 2010

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Article

PKCε induces Bcl-2 by activating CREB

Eswar Shankar, Soumya Krishnamurthy, Rajiv Paranandi, Alakananda Basu
Pages: 883-888
Published online on: 01 April 2010

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Immunohistochemical profiling of node negative breast carcinomas allows prediction of metastatic risk

Sophie Giusiano, Veronique Secq, Xavier Carcopino, Severine Carpentier, Lucile Andrac, Marie-Noelle Lavaut, Claude Allasia, Pascal Bonnier, Juan Lucio Iovanna, Stephane Garcia, Leon Boubli, Daniel Birnbaum, Colette Charpin
Pages: 889-898
Published online on: 01 April 2010

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Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells

Chunli Li, Dingbin Liu, Ying Yuan, Shifeng Huang, Meng Shi, Kun Tao, Wenli Feng
Pages: 899-904
Published online on: 01 April 2010

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Article

A new system for regulated functional gene expression for gene therapy applications: Nuclear delivery of a p16INK4A-estrogen receptor carboxy terminal fusion protein only in the presence of estrogen

Tomohiro Tamura, Tatsuya Kanuma, Tomoko Nakazato, Leri S. Faried, Hiroshi Aoki, Takashi Minegishi
Pages: 905-912
Published online on: 01 April 2010

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Article

miR-221/222 promote malignant progression of glioma through activation of the Akt pathway Expression of Concern in /10.3892/ijo.2025.5808

Junxia Zhang, Lei Han, Youlin Ge, Xuan Zhou, Anling Zhang, Chunzhi Zhang, Yue Zhong, Yongping You, Peiyu Pu, Chunsheng Kang
Pages: 913-920
Published online on: 01 April 2010

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Article

17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells

Young-Ju Jeong, Eun-Mi Noh, Young-Rae Lee, Hong-Nu Yu, Kyu-Yun Jang, Seung Jin Lee, Jonghyeon Kim, Jong-Suk Kim
Pages: 921-927
Published online on: 01 April 2010

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Article

Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones

Kristin Mrasek, Christiane Schoder, Anne-Christin Teichmann, Katja Behr, Britta Franze, Kathleen Wilhelm, Nancy Blaurock, Uwe Claussen, Thomas Liehr, Anja Weise
Pages: 929-940
Published online on: 01 April 2010

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Article

Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IκB/NF-κB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway

Hwa Young Lee, Suzanne Crawley, Ryota Hokari, Sungwon Kwon, Young S. Kim
Pages: 941-953
Published online on: 01 April 2010

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Article

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability

Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl, Ulrich Mahlknecht
Pages: 955-960
Published online on: 01 April 2010

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Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315

El-Hadj Saidou Balde, Véronique Mégalizzi, Martine Cao, Luc Angenot, Robert Kiss, Marc Van Damme, Michel Frederich
Pages: 961-965
Published online on: 01 April 2010

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Article

Effects of an EGFR-binding affibody molecule on intracellular signaling pathways

E. Nordberg, L. Ekerljung, S. H. Sahlberg, J. Carlsson, J. Lennartsson, B. Glimelius
Pages: 967-972
Published online on: 01 April 2010

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Article

Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine

Richard J.E. Skipworth, Grant D. Stewart, Mishaim Bhana, Jennifer Christie, Catharine M. Sturgeon, Denis C. Guttridge, Andrew D. Cronshaw, Kenneth C.H. Fearon, James A. Ross
Pages: 973-982
Published online on: 01 April 2010

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Article

Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage

Juliana De Moura, Flávia Ludimila Kavalec, Mabrouka Doghman, Roberto Rosati, Gislaine Custodio, Enzo Lalli, Glaci Moura D. Cavallari, Jesus Santa Maria, Bonald C. Figueiredo
Pages: 983-990
Published online on: 01 April 2010

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Article

The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation

Carol Yee-Ki Lee, Wai-Hung Sit, Sheung-Tat Fan, Kwan Man, Irene Wing-Yan Jor, Leo Lap-Yan Wong, Murphy Lam-Yim Wan, Kian Cheng Tan-Un, Jennifer Man-Fan Wan
Pages: 991-998
Published online on: 01 April 2010

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Article

Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: Perspectives for therapeutics

Xiaoling Zhou, Xu-Yu Yang, Nicholas C. Popescu
Pages: 999-1005
Published online on: 01 April 2010

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Article

Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation

Hee Jung Um, Jae Hoon Bae, Jong-Wook Park, Hongsuk Suh, Na Young Jeong, Young Hyun Yoo, Taeg Kyu Kwon
Pages: 1007-1013
Published online on: 01 April 2010

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Article

Porcupine expression is associated with the expression of S100P and other cancer-related molecules in non-small cell lung carcinoma

Babett Bartling, Grit Rehbein, Andreas Simm, Rolf-Edgar Silber, Hans-Stefan Hofmann
Pages: 1015-1021
Published online on: 01 April 2010

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Article

Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation

Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N. Johnston, Young-Hwa Chung
Pages: 1023-1030
Published online on: 01 April 2010

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Article

Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells

Wenjing Zhang, Zheng Guo, Bo Jiang, Lingyun Niu, Guosheng Xia, Xinying Wang, Tianming Cheng, Yusheng Zhang, Jide Wang
Pages: 1031-1037
Published online on: 01 April 2010

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Article

Increase of the therapeutic effect by treating nasopharyngeal tumor with combination of HER-2 siRNA and paclitaxel

Yoshiyuki Hattori, Motoki Hakoshima, Kimiko Koga, Yoshie Maitani
Pages: 1039-1046
Published online on: 01 April 2010

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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