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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2010 Volume 36 Issue 4

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

Quantification of internalization of EGFR-binding Affibody molecules: Methodological aspects

Lovisa Göstring, Ming Tsuey Chew, Anna Orlova, Ingmarie Höidén-Guthenberg, Anders Wennborg, Jörgen Carlsson, Fredrik Y. Frejd
Pages: 757-763
Published online on: 01 April 2010

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Article

MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues

Keisuke Okudaira, Sanjay Kakar, Lisa Cun, Ester Choi, Rina Wu DeCamillis, Soichiro Miura, Marvin H. Sleisenger, Young S. Kim, Gouren Deng
Pages: 765-775
Published online on: 01 April 2010

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Article

Targeted photodynamic therapy for prostate cancer: Inducing apoptosis via activation of the caspase-8/-3 cascade pathway

Tiancheng Liu, Lisa Y. Wu, Joseph K. Choi, Clifford E. Berkman
Pages: 777-784
Published online on: 01 April 2010

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Article

HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo

Paolo Fiorenzo, Maria Patrizia Mongiardi, Diletta Dimitri, Mauro Cozzolino, Alberto Ferri, Nicola Montano, Gianluca Trevisi, Giulio Maira, Luca Battistini, Maria Laura Falchetti, Andrea Levi, Roberto Pallini
Pages: 785-791
Published online on: 01 April 2010

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Article

Tumor-derived trypsin enhances proliferation of intrahepatic cholangiocarcinoma cells by activating protease-activated receptor-2

Shin-Ichi Nakanuma, Hidehiro Tajima, Kouichi Okamoto, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Tetsuo Ohta, Tomohiko Wakayama, Shoichi Iseki, Shin-Ichi Harada
Pages: 793-800
Published online on: 01 April 2010

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Article

Photoactivation of 9-hydroxypheophorbide α triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells

Peijie He, Jin-Chul Ahn, Jang-In Shin, Phil-Sang Chung
Pages: 801-808
Published online on: 01 April 2010

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Article

Radiation-inducible silencing of uPA and uPAR in vitro and in vivo in meningioma Retraction in /10.3892/ijo.2026.5890

Venkateswara Rao Gogineni, Arun Kumar Nalla, Reshu Gupta, Bharathi Gorantla, Meena Gujrati, Dzung H. Dinh, Jasti S. Rao
Pages: 809-816
Published online on: 01 April 2010

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Article

Upregulation of Notch pathway molecules in oral squamous cell carcinoma

Hiroshi Hijioka, Takao Setoguchi, Akihiko Miyawaki, Hui Gao, Takayuki Ishida, Setsuro Komiya, Norifumi Nakamura
Pages: 817-822
Published online on: 01 April 2010

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Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo

Satoshi Takenaka, Norifumi Naka, Nobuhito Araki, Nobuyuki Hashimoto, Takafumi Ueda, Kiyoko Yoshioka, Hideki Yoshikawa, Kazuyuki Itoh
Pages: 823-831
Published online on: 01 April 2010

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Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP

Ondrej Tolde, Daniel Rösel, Claudia T. Mierke, Daniela Panková, Petr Folk, Pavel Vesely, Jan Brábek
Pages: 833-839
Published online on: 01 April 2010

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Article

Regulatory T cell depletion enhances tumor specific CD8 T-cell responses, elicited by tumor antigen NY-ESO-1b in hepatocellular carcinoma patients, in vitro

Heng-Hui Zhang, Ming-Hui Mei, Ran Fei, Wei-Jia Liao, Xue-Yan Wang, Li-Ling Qin, Jiang-Hua Wang, Lai Wei, Hong-Song Chen
Pages: 841-848
Published online on: 01 April 2010

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Development of an oral cancer recurrence mouse model after surgical resection

Andreas Behren, York Kamenisch, Sabrina Muehlen, Christa Flechtenmacher, Uwe Haberkorn, Hermann Hilber, Jeffrey N. Myers, Zazie Bergmann, Peter Karl Plinkert, Christian Simon
Pages: 849-855
Published online on: 01 April 2010

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Article

Carvedilol in glioma treatment alone and with imatinib in vitro

Mine Erguven, Nuray Yazihan, Esin Aktas, Akin Sabanci, Chiang J. Li, Gulperi Oktem, Ayhan Bilir
Pages: 857-866
Published online on: 01 April 2010

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The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells

Soo-A Kim, Seong-Min Kwon, Jung-Hoon Yoon, Sang-Gun Ahn
Pages: 867-872
Published online on: 01 April 2010

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Targeting the cell cycle and the PI3K pathway: A possible universal strategy to reactivate innate tumor suppressor programmes in cancer cells

Thérèse David-Pfeuty, Michel Legraverend, Odile Ludwig, David S. Grierson
Pages: 873-881
Published online on: 01 April 2010

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Article

PKCε induces Bcl-2 by activating CREB

Eswar Shankar, Soumya Krishnamurthy, Rajiv Paranandi, Alakananda Basu
Pages: 883-888
Published online on: 01 April 2010

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Immunohistochemical profiling of node negative breast carcinomas allows prediction of metastatic risk

Sophie Giusiano, Veronique Secq, Xavier Carcopino, Severine Carpentier, Lucile Andrac, Marie-Noelle Lavaut, Claude Allasia, Pascal Bonnier, Juan Lucio Iovanna, Stephane Garcia, Leon Boubli, Daniel Birnbaum, Colette Charpin
Pages: 889-898
Published online on: 01 April 2010

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Article

Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells

Chunli Li, Dingbin Liu, Ying Yuan, Shifeng Huang, Meng Shi, Kun Tao, Wenli Feng
Pages: 899-904
Published online on: 01 April 2010

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A new system for regulated functional gene expression for gene therapy applications: Nuclear delivery of a p16INK4A-estrogen receptor carboxy terminal fusion protein only in the presence of estrogen

Tomohiro Tamura, Tatsuya Kanuma, Tomoko Nakazato, Leri S. Faried, Hiroshi Aoki, Takashi Minegishi
Pages: 905-912
Published online on: 01 April 2010

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Article

miR-221/222 promote malignant progression of glioma through activation of the Akt pathway Expression of Concern in /10.3892/ijo.2025.5808 Corrigendum in /10.3892/ijo.2026.5937

Junxia Zhang, Lei Han, Youlin Ge, Xuan Zhou, Anling Zhang, Chunzhi Zhang, Yue Zhong, Yongping You, Peiyu Pu, Chunsheng Kang
Pages: 913-920
Published online on: 01 April 2010

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Article

17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells

Young-Ju Jeong, Eun-Mi Noh, Young-Rae Lee, Hong-Nu Yu, Kyu-Yun Jang, Seung Jin Lee, Jonghyeon Kim, Jong-Suk Kim
Pages: 921-927
Published online on: 01 April 2010

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Article

Global screening and extended nomenclature for 230 aphidicolin-inducible fragile sites, including 61 yet unreported ones

Kristin Mrasek, Christiane Schoder, Anne-Christin Teichmann, Katja Behr, Britta Franze, Kathleen Wilhelm, Nancy Blaurock, Uwe Claussen, Thomas Liehr, Anja Weise
Pages: 929-940
Published online on: 01 April 2010

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Article

Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IκB/NF-κB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway

Hwa Young Lee, Suzanne Crawley, Ryota Hokari, Sungwon Kwon, Young S. Kim
Pages: 941-953
Published online on: 01 April 2010

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Article

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability

Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl, Ulrich Mahlknecht
Pages: 955-960
Published online on: 01 April 2010

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Article

Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, with potential anti-tumor activity against apoptosis-resistant cancer cells Corrigendum in /ijo/36/5/1315

El-Hadj Saidou Balde, Véronique Mégalizzi, Martine Cao, Luc Angenot, Robert Kiss, Marc Van Damme, Michel Frederich
Pages: 961-965
Published online on: 01 April 2010

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Article

Effects of an EGFR-binding affibody molecule on intracellular signaling pathways

E. Nordberg, L. Ekerljung, S. H. Sahlberg, J. Carlsson, J. Lennartsson, B. Glimelius
Pages: 967-972
Published online on: 01 April 2010

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Article

Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine

Richard J.E. Skipworth, Grant D. Stewart, Mishaim Bhana, Jennifer Christie, Catharine M. Sturgeon, Denis C. Guttridge, Andrew D. Cronshaw, Kenneth C.H. Fearon, James A. Ross
Pages: 973-982
Published online on: 01 April 2010

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Article

Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage

Juliana De Moura, Flávia Ludimila Kavalec, Mabrouka Doghman, Roberto Rosati, Gislaine Custodio, Enzo Lalli, Glaci Moura D. Cavallari, Jesus Santa Maria, Bonald C. Figueiredo
Pages: 983-990
Published online on: 01 April 2010

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Article

The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation

Carol Yee-Ki Lee, Wai-Hung Sit, Sheung-Tat Fan, Kwan Man, Irene Wing-Yan Jor, Leo Lap-Yan Wong, Murphy Lam-Yim Wan, Kian Cheng Tan-Un, Jennifer Man-Fan Wan
Pages: 991-998
Published online on: 01 April 2010

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Article

Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: Perspectives for therapeutics

Xiaoling Zhou, Xu-Yu Yang, Nicholas C. Popescu
Pages: 999-1005
Published online on: 01 April 2010

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Article

Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation

Hee Jung Um, Jae Hoon Bae, Jong-Wook Park, Hongsuk Suh, Na Young Jeong, Young Hyun Yoo, Taeg Kyu Kwon
Pages: 1007-1013
Published online on: 01 April 2010

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Article

Porcupine expression is associated with the expression of S100P and other cancer-related molecules in non-small cell lung carcinoma

Babett Bartling, Grit Rehbein, Andreas Simm, Rolf-Edgar Silber, Hans-Stefan Hofmann
Pages: 1015-1021
Published online on: 01 April 2010

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Article

Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation

Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N. Johnston, Young-Hwa Chung
Pages: 1023-1030
Published online on: 01 April 2010

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Article

Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells

Wenjing Zhang, Zheng Guo, Bo Jiang, Lingyun Niu, Guosheng Xia, Xinying Wang, Tianming Cheng, Yusheng Zhang, Jide Wang
Pages: 1031-1037
Published online on: 01 April 2010

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Article

Increase of the therapeutic effect by treating nasopharyngeal tumor with combination of HER-2 siRNA and paclitaxel

Yoshiyuki Hattori, Motoki Hakoshima, Kimiko Koga, Yoshie Maitani
Pages: 1039-1046
Published online on: 01 April 2010

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Journal Cover
November-2026 Volume 69 Issue 5

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review Open Access

Resistance to covalent Bruton's tyrosine kinase inhibitors in diffuse large B‑cell lymphoma: Molecular mechanisms and therapeutic implications (Review)

Chuanyang Lu, Tingting Zhou, Wenxin Zhang, Lulu Wei, Qiuni Chen, Yuye Shi, Chunling Wang, Liang Yu
Article Number: 134
Published online on: 09 October 2026

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Review Open Access

Comprehensive landscape and future perspectives of PIWI‑interacting RNAs in cancer (Review)

Xiaoqian Yu, Changlong Li, Tongtao Zhuang, Siqing Sun, Xiaoyun He, Zhenyu Ou, Nannan Li, Chunlin Ou
Article Number: 133
Published online on: 09 October 2026

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Review Open Access

Nucleocytoplasmic transport in gynaecological cancer: From mechanisms to therapeutic potential (Review)

Ieva Norkaityte, Laura Marija Racyte, Egle Balciunaite, Aiste Avizaite, Egle Zalyte
Article Number: 132
Published online on: 08 October 2026

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Review Open Access

cGAS‑STING pathway in digestive tract cancer: From molecular mechanisms to therapeutic applications (Review)

Tangna Chen, Jingyi Zhang, Jinghan Sun, Hongyan Zhang, Deqiang Huang, Haifeng Ye
Article Number: 131
Published online on: 07 October 2026

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Review Open Access

Regulatory T cells in lung adenocarcinoma: Mechanisms of immune escape, prognostic significance and therapeutic opportunities (Review)

Lijuan Wang, Chenjin Ruan
Article Number: 130
Published online on: 06 October 2026

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Retraction Open Access

[Retracted] In vitro modulation of MMP‑2 and MMP‑9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors

M.W. Roomi, T. Kalinovsky, J.  Monterrey, M. Rath, A. Niedzwiecki
Article Number: 129
Published online on: 21 September 2026

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Review Open Access

Eomesodermin in renal cell carcinoma: Epigenetic and immune crosstalk driving tumor progression (Review)

Zhifei Che, Dongwen Huang, Jiaming Lin, Xincen Wang, Rongjin Feng, Xianping Che, Yubin Wang
Article Number: 128
Published online on: 18 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ultraviolet exposure of melanoma cells induces fibroblast activation protein‑α in fibroblasts: Implications for melanoma invasion

Petra Wäster, Inger Rosdahl, Brendan F.  Gilmore, Oliver Seifert
Article Number: 127
Published online on: 16 September 2026

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Article Open Access

E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway

Ye Liang, Jie Zhuang
Article Number: 126
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter, Christian D. Muller, Ali Hamiche, Yves Mély, Christian Bronner, Marc Mousli
Article Number: 125
Published online on: 14 September 2026

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Correction Open Access

[Corrigendum] miR‑221/222 promote malignant progression of glioma through activation of the Akt pathway

Junxia Zhang, Lei Han, Youlin Ge, Xuan Zhou, Anling Zhang, Chunzhi Zhang, Yue Zhong, Yongping You, Peiyu Pu, Chunsheng Kang
Article Number: 124
Published online on: 03 September 2026

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Review Open Access

Dendritic cell‑based vaccines for colorectal cancer: Mechanisms, clinical progress and future directions (Review)

Lian Yih Pong, Siti Ayuni Hassanudin, Seng Kong Tham, Ravichandran Manickam, Chee Yin Wong, Keat Seong Poh, Chit Laa Poh
Article Number: 123
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] Pro‑metastatic intracellular signaling of the elaidic trans fatty acid

Kiyomu Fujii, Yi Luo, Rina Fujiwara-tani, Shingo Kishi, Song He, Shuyun Yang, Takamitsu Sasaki, Hitoshi Ohmori, Hiroki Kuniyasu
Article Number: 122
Published online on: 02 September 2026

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Journal Cover
December-2026 Volume 69 Issue 6

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Journal Metrics

Impact Factor: 7.3

CiteScore: 10.2

CiteScore Rank: Q1: #51/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Correction Open Access

[Corrigendum] Monoamine carboxylate transporters are involved in BI-1-associated cancer metastasis in HT1080 colon fibrosarcoma cells

Geum-Hwa Lee, Han-Jung Chae, Hyung-Ryong Kim
Article Number: 138
Published online on: 19 October 2026

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Article Open Access

Disporum cantoniense suppresses non‑small cell lung cancer through AMPK/mTOR/ULK1‑mediated autophagy‑dependent apoptosis

Chi Feng, Yujiao Ji, Renqiang Chen, Qiuxu Chen, Yiru Pan, Jianming Wu, Dalian Qin, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Xiaogang Zhou, Jianxin Liu, Anguo Wu
Article Number: 137
Published online on: 15 October 2026

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Review Open Access

Research progress of SPP1 in cancer regulation: Tumorigenesis, metastasis, tumor microenvironment, immunity and therapeutic targets (Review)

Yujun Xia, Dong Han, Song Tang, Huimin Yang, Rongjie Zhao, Beibei Cao, Peixi Zhu, Aiqin Shi, Huacheng Luo
Article Number: 136
Published online on: 14 October 2026

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Correction Open Access

[Corrigendum] Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER‑inhibitors is accompanied by increased sensitivity to STAT3 inhibition

Nikolaos Ioannou, Alan M. Seddon, Angus Dalgleish, David Mackintosh, Flavio Solca, Helmout Modjtahedi
Article Number: 135
Published online on: 09 October 2026

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