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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2010 Volume 36 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2010 Volume 36 Issue 4

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Article

The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells

  • Authors:
    • Soo-A Kim
    • Seong-Min Kwon
    • Jung-Hoon Yoon
    • Sang-Gun Ahn
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714, Korea
  • Pages: 867-872
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/ijo_00000564
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Abstract

High levels of mitotic progression-associated PLK1 and stress-associated HSF1 have been observed in various human cancers. In the present study, we investigated the effects of PLK1 and HSF1 knockdown on the proliferation of oral cancer cells using small interfering RNA. In human oral squamous cell carcinoma (SCC) tissues, the levels of PLK1 and HSF1 were higher compared to normal tissues. The expression levels of PLK1 and HSF1 were also elevated in the human oral SCC cell lines FaDu and HEp-2. Disruption of PLK1 induced cell cycle arrest at G2/M phase as well as apoptosis in oral cancer cells. Interestingly, knockdown of both PLK1 and HSF1 expression decreased cell proliferation while increasing apoptotic cell death in synergistic fashion. These results establish the potential value of PLK1 and HSF1 as targets for oral cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Kwon S, Yoon J and Ahn S: The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. Int J Oncol 36: 867-872, 2010.
APA
Kim, S., Kwon, S., Yoon, J., & Ahn, S. (2010). The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. International Journal of Oncology, 36, 867-872. https://doi.org/10.3892/ijo_00000564
MLA
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36.4 (2010): 867-872.
Chicago
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36, no. 4 (2010): 867-872. https://doi.org/10.3892/ijo_00000564
Copy and paste a formatted citation
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Spandidos Publications style
Kim S, Kwon S, Yoon J and Ahn S: The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. Int J Oncol 36: 867-872, 2010.
APA
Kim, S., Kwon, S., Yoon, J., & Ahn, S. (2010). The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. International Journal of Oncology, 36, 867-872. https://doi.org/10.3892/ijo_00000564
MLA
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36.4 (2010): 867-872.
Chicago
Kim, S., Kwon, S., Yoon, J., Ahn, S."The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells". International Journal of Oncology 36, no. 4 (2010): 867-872. https://doi.org/10.3892/ijo_00000564
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