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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2010 Volume 36 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2010 Volume 36 Issue 4

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Article

17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells

  • Authors:
    • Young-Ju Jeong
    • Eun-Mi Noh
    • Young-Rae Lee
    • Hong-Nu Yu
    • Kyu-Yun Jang
    • Seung Jin Lee
    • Jonghyeon Kim
    • Jong-Suk Kim

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Chonbuk National University Medical School, Jeonju 561-180, Korea
  • Pages: 921-927
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/ijo_00000571
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Abstract

The tumor suppressor protein, PTEN (phosphatase and tensin homologue), has been reported to play a crucial role in a variety of tumor cells. Recent studies indicate that the transcription factor, PPARγ (peroxisome proliferator-activated receptor γ) up-regulates PTEN expression transcriptionally through the binding of two response elements in the genomic sequence upstream of PTEN in tumor cells. Here, we determined the PTEN and PPARγ expression in human leiomyomas, and whether estrogen can change their protein expressions in cultured leiomyoma cells. Immunohistochemical staining and Western blot analysis revealed that PTEN protein levels in leiomyomas were higher than that the adjacent normal myometrial tissues, which was paralleled with decrease in phospho-Akt (ser-473) and phosphatidylinositol 3,4,5-tris phosphate (PIP3) level. Interestingly, leiomyomas exhibit high PPARγ expression compared to the adjacent normal myometrial tissues. In addition, we found that 17β-estradiol (E2) significantly stimulated PTEN and PPARγ expression in cultured leiomyoma cells, but did not change both protein levels in normal cells. This report shows the first evidence that PTEN and PPARγ are up-regulated in leiomyoma tissues, and estrogen stimulates expression of PTEN and PPARγ in leiomyoma cells, but not in normal cells.

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Copy and paste a formatted citation
Spandidos Publications style
Jeong Y, Noh E, Lee Y, Yu H, Jang K, Lee SJ, Kim J and Kim J: 17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells. Int J Oncol 36: 921-927, 2010.
APA
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S.J. ... Kim, J. (2010). 17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells. International Journal of Oncology, 36, 921-927. https://doi.org/10.3892/ijo_00000571
MLA
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S. J., Kim, J., Kim, J."17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells". International Journal of Oncology 36.4 (2010): 921-927.
Chicago
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S. J., Kim, J., Kim, J."17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells". International Journal of Oncology 36, no. 4 (2010): 921-927. https://doi.org/10.3892/ijo_00000571
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong Y, Noh E, Lee Y, Yu H, Jang K, Lee SJ, Kim J and Kim J: 17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells. Int J Oncol 36: 921-927, 2010.
APA
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S.J. ... Kim, J. (2010). 17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells. International Journal of Oncology, 36, 921-927. https://doi.org/10.3892/ijo_00000571
MLA
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S. J., Kim, J., Kim, J."17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells". International Journal of Oncology 36.4 (2010): 921-927.
Chicago
Jeong, Y., Noh, E., Lee, Y., Yu, H., Jang, K., Lee, S. J., Kim, J., Kim, J."17β-estradiol induces up-regulation of PTEN and PPARγ in leiomyoma cells, but not in normal cells". International Journal of Oncology 36, no. 4 (2010): 921-927. https://doi.org/10.3892/ijo_00000571
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