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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2010 Volume 36 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2010 Volume 36 Issue 4

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Article

Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells

  • Authors:
    • Wenjing Zhang
    • Zheng Guo
    • Bo Jiang
    • Lingyun Niu
    • Guosheng Xia
    • Xinying Wang
    • Tianming Cheng
    • Yusheng Zhang
    • Jide Wang

  • View Affiliations / Copyright

    Affiliations: Department of Digestive Medicine, Nanfang Hospital, The Southern Medical University, Guangzhou 510515, P.R. China
  • Pages: 1031-1037
    |
    Published online on: April 1, 2010
       https://doi.org/10.3892/ijo_00000584
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Abstract

It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the recombinant p53 protein was examined. Site-directed mutation of putative p53 binding sequence and p53 knockdown by siRNA were performed. The protein expression and promoter activities of XAF1 in cells with null p53 were higher than that with wild-type and mutant p53. Ectopic overexpression of wild-type p53 suppressed XAF1 expression. A half-site (−95 to −86 nt) and a quarter-site (−4 to +1 nt) of p53 responsive element were found within XAF1 promoter. Both sequences bound to recombinant p53 effectively and specifically. Site-mutation of p53 responsive sequences abrogated the binding capacity. However, only the mutation of half-site increased XAF1 promoter activities. Suppression of p53 not only decreased the binding capacity of p53 responsive halfsite but also increased XAF1 transcription. In conclusion, we demonstrated that p53 could suppress the transcription of XAF1 through interaction with a high affinity responsive element (−95 to −86 nt) within XAF1 promoter, indicating a novel exclusive mechanism between these two tumor suppressors.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Guo Z, Jiang B, Niu L, Xia G, Wang X, Cheng T, Zhang Y and Wang J: Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells. Int J Oncol 36: 1031-1037, 2010.
APA
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X. ... Wang, J. (2010). Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells. International Journal of Oncology, 36, 1031-1037. https://doi.org/10.3892/ijo_00000584
MLA
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X., Cheng, T., Zhang, Y., Wang, J."Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells". International Journal of Oncology 36.4 (2010): 1031-1037.
Chicago
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X., Cheng, T., Zhang, Y., Wang, J."Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells". International Journal of Oncology 36, no. 4 (2010): 1031-1037. https://doi.org/10.3892/ijo_00000584
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Guo Z, Jiang B, Niu L, Xia G, Wang X, Cheng T, Zhang Y and Wang J: Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells. Int J Oncol 36: 1031-1037, 2010.
APA
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X. ... Wang, J. (2010). Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells. International Journal of Oncology, 36, 1031-1037. https://doi.org/10.3892/ijo_00000584
MLA
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X., Cheng, T., Zhang, Y., Wang, J."Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells". International Journal of Oncology 36.4 (2010): 1031-1037.
Chicago
Zhang, W., Guo, Z., Jiang, B., Niu, L., Xia, G., Wang, X., Cheng, T., Zhang, Y., Wang, J."Identification of a functional p53 responsive element within the promoter of XAF1 gene in gastrointestinal cancer cells". International Journal of Oncology 36, no. 4 (2010): 1031-1037. https://doi.org/10.3892/ijo_00000584
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