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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2010 Volume 36 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2010 Volume 36 Issue 6

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Article

Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma

  • Authors:
    • Yuki Takayama
    • Taisuke Mori
    • Takeshi Nomura
    • Takahiko Shibahara
    • Michiie Sakamoto

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Mihama-ku, Chiba 261-8502, Japan
  • Pages: 1387-1394
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/ijo_00000623
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Abstract

Bone invasion is a critical prognostic factor for patients with oral squamous cell carcinoma (OSCC). We established an orthotropic implantation model using the murine OSCC cell line, SCCVII, showing direct invasion of the mandible by OSCC. Using this model, we examined the molecular mechanisms of bone invasion and the role of parathyroid-related protein (PTHrP). We established PTHrP, stable, knock-down SCCVII cells. Knock-down of PTHrP caused decreased osteoclast formation in vitro relative to expression levels of PTHrP. In vivo models showed dramatic suppression of bone invasion in PTHrP knock-down cells, and the degree of suppression was more pronounced than the level of PTHrP knock-down. We looked at an additive role of transforming growth factor-β (TGF-β) in PTHrP-mediated bone invasion. TGF-β induced mRNA expression of PTHrP, showed no inhibitory effect on SCCVII cell proliferation, and caused epithelial mesenchymal trans-differentiation such as changes in the cells. Sections of resected mandibles from patients with invasive OSCC showed a great number of osteoclasts at bone invasion sites, strong expression of PTHrP, and decreased expression of E-cadherin in the tumour cells. Cancer-derived PTHrP appears to play a critical role in bone invasion by OSCC, mediated by osteoclasts. Moreover, TGF-β appears to act synergistically to accelerate mandibular bone invasion.

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Copy and paste a formatted citation
Spandidos Publications style
Takayama Y, Mori T, Nomura T, Shibahara T and Sakamoto M: Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma. Int J Oncol 36: 1387-1394, 2010.
APA
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., & Sakamoto, M. (2010). Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma. International Journal of Oncology, 36, 1387-1394. https://doi.org/10.3892/ijo_00000623
MLA
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., Sakamoto, M."Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma". International Journal of Oncology 36.6 (2010): 1387-1394.
Chicago
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., Sakamoto, M."Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma". International Journal of Oncology 36, no. 6 (2010): 1387-1394. https://doi.org/10.3892/ijo_00000623
Copy and paste a formatted citation
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Spandidos Publications style
Takayama Y, Mori T, Nomura T, Shibahara T and Sakamoto M: Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma. Int J Oncol 36: 1387-1394, 2010.
APA
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., & Sakamoto, M. (2010). Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma. International Journal of Oncology, 36, 1387-1394. https://doi.org/10.3892/ijo_00000623
MLA
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., Sakamoto, M."Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma". International Journal of Oncology 36.6 (2010): 1387-1394.
Chicago
Takayama, Y., Mori, T., Nomura, T., Shibahara, T., Sakamoto, M."Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma". International Journal of Oncology 36, no. 6 (2010): 1387-1394. https://doi.org/10.3892/ijo_00000623
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