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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2010 Volume 36 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2010 Volume 36 Issue 6

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Article

Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer

  • Authors:
    • Sivalokanathan Sarveswaran
    • Joshua Liroff
    • Zongxiang Zhou
    • Alexander Y. Nikitin
    • Jagadananda Ghosh

  • View Affiliations / Copyright

    Affiliations: The Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI 48202, USA
  • Pages: 1419-1428
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/ijo_00000627
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Abstract

Supra-nutritional selenium supplementation has emerged as an attractive new approach to intervene in a range of human cancers, in particular prostate cancer. However, scanty information is currently available on molecular mechanisms underlying selenium's anticancer action. The tumor suppressor p53 plays an important role in preventing transformation by transcriptional regulation of a range of genes that are involved in vital cell functions such as DNA repair, cell cycle arrest, and induction of apoptosis. Here we report that incubation of LNCaP human prostate cancer cells (p53 +/+) with a natural form of selenium triggers rapid transcriptional activation of p53, and up-regulation of the expression of p53-target genes as well as induction of miR-34 class of microRNAs. Moreover, blocking p53 function by transfection of cells with a dominant-negative, mutated p53 gene, or by siRNA, significantly reduced selenium-induced expression of p53-target genes and induction of apoptosis. Since majority of the early-stage human prostate cancers bear functional p53 gene (p53+/+), our findings indicate that the anticancer action of selenium may involve transactivation of p53 as a potential mechanism, and suggest that selenite may be useful not only for prevention but also for treatment of human prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sarveswaran S, Liroff J, Zhou Z, Nikitin AY and Ghosh J: Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. Int J Oncol 36: 1419-1428, 2010.
APA
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A.Y., & Ghosh, J. (2010). Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. International Journal of Oncology, 36, 1419-1428. https://doi.org/10.3892/ijo_00000627
MLA
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Y., Ghosh, J."Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer". International Journal of Oncology 36.6 (2010): 1419-1428.
Chicago
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Y., Ghosh, J."Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer". International Journal of Oncology 36, no. 6 (2010): 1419-1428. https://doi.org/10.3892/ijo_00000627
Copy and paste a formatted citation
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Spandidos Publications style
Sarveswaran S, Liroff J, Zhou Z, Nikitin AY and Ghosh J: Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. Int J Oncol 36: 1419-1428, 2010.
APA
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A.Y., & Ghosh, J. (2010). Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. International Journal of Oncology, 36, 1419-1428. https://doi.org/10.3892/ijo_00000627
MLA
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Y., Ghosh, J."Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer". International Journal of Oncology 36.6 (2010): 1419-1428.
Chicago
Sarveswaran, S., Liroff, J., Zhou, Z., Nikitin, A. Y., Ghosh, J."Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer". International Journal of Oncology 36, no. 6 (2010): 1419-1428. https://doi.org/10.3892/ijo_00000627
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