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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2010 Volume 36 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC

  • Authors:
    • Chang-Kyu Heo
    • Mi-Kyung Woo
    • Dae-Yeul Yu
    • Ju Yeon Lee
    • Jong Shin Yoo
    • Hyang Sook Yoo
    • Jeong Heon Ko
    • Jin-Man Kim
    • Jong Young Choi
    • In Gyu Kim
    • Sang Gi Paik
    • Eun-Wie Cho
  • View Affiliations / Copyright

    Affiliations: Daejeon-KRIBB-FHCRC Research Cooperation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 305-860, Korea
  • Pages: 1453-1459
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/ijo_00000631
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Abstract

Autoantibodies, which are generated by immune system recognizing the presence of the abnormal tumor-associated antigens, are promising biomarkers for early detection of tumors. Recently, we established a B cell hybridoma pool derived from H-ras12V transgenic mouse, a typical hepatocellular carcinoma model, as a source of tumor-associated autoantibodies without using any extracellular antigens and have characterized the specific target antigens against them. K1 autoantibody, one of them, was investigated in this study and its target antigen was identified by mass spectrometric analysis as fatty acid synthase (FASN), an important oncogenic protein. Moreover, a specific mimotope against K1 autoantibody was screened from the cyclic random hepta-peptide phage library and, using it as a coating antigen for ELISA, we could distinguish patients with hepatocellular carcinoma (HCC) vs. normal subjects with 96.55% sensitivity and 100% specificity. These results imply that anti-FASN autoantibody is induced in patients with HCC and detection of anti-FASN autoantibody can be used for the diagnosis of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Heo C, Woo M, Yu D, Lee JY, Yoo JS, Yoo HS, Ko JH, Kim J, Choi JY, Kim IG, Kim IG, et al: Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. Int J Oncol 36: 1453-1459, 2010.
APA
Heo, C., Woo, M., Yu, D., Lee, J.Y., Yoo, J.S., Yoo, H.S. ... Cho, E. (2010). Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. International Journal of Oncology, 36, 1453-1459. https://doi.org/10.3892/ijo_00000631
MLA
Heo, C., Woo, M., Yu, D., Lee, J. Y., Yoo, J. S., Yoo, H. S., Ko, J. H., Kim, J., Choi, J. Y., Kim, I. G., Paik, S. G., Cho, E."Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC". International Journal of Oncology 36.6 (2010): 1453-1459.
Chicago
Heo, C., Woo, M., Yu, D., Lee, J. Y., Yoo, J. S., Yoo, H. S., Ko, J. H., Kim, J., Choi, J. Y., Kim, I. G., Paik, S. G., Cho, E."Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC". International Journal of Oncology 36, no. 6 (2010): 1453-1459. https://doi.org/10.3892/ijo_00000631
Copy and paste a formatted citation
x
Spandidos Publications style
Heo C, Woo M, Yu D, Lee JY, Yoo JS, Yoo HS, Ko JH, Kim J, Choi JY, Kim IG, Kim IG, et al: Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. Int J Oncol 36: 1453-1459, 2010.
APA
Heo, C., Woo, M., Yu, D., Lee, J.Y., Yoo, J.S., Yoo, H.S. ... Cho, E. (2010). Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. International Journal of Oncology, 36, 1453-1459. https://doi.org/10.3892/ijo_00000631
MLA
Heo, C., Woo, M., Yu, D., Lee, J. Y., Yoo, J. S., Yoo, H. S., Ko, J. H., Kim, J., Choi, J. Y., Kim, I. G., Paik, S. G., Cho, E."Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC". International Journal of Oncology 36.6 (2010): 1453-1459.
Chicago
Heo, C., Woo, M., Yu, D., Lee, J. Y., Yoo, J. S., Yoo, H. S., Ko, J. H., Kim, J., Choi, J. Y., Kim, I. G., Paik, S. G., Cho, E."Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC". International Journal of Oncology 36, no. 6 (2010): 1453-1459. https://doi.org/10.3892/ijo_00000631
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