Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9

  • Authors:
    • Sabrina Mühlen
    • Andreas Behren
    • Thomas Iftner
    • Christian Simon
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/ijo_00000682
  • Pages: 337-345
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Abstract

Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (MMP-9); a protease known to play a key role in invasion and metastasis. However, as of now we do not understand the underlying mechanism of activation nor relevance for the human system. Here, we report that high-risk human papillomavirus HPV16 E2 similar to our previously reported results on CRPV E2 activates the human MMP-9 promoter predominantly via the MEK1-ERK1/2-AP-1-signaling pathway. In addition this activation is associated with a nuclear sub-localisation of HPV16-E2 suggesting a nuclear protein-protein or protein-DNA interaction of E2 as the underlying mechanism of activation.

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August 2010
Volume 37 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mühlen S, Behren A, Iftner T and Simon C: Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9. Int J Oncol 37: 337-345, 2010
APA
Mühlen, S., Behren, A., Iftner, T., & Simon, C. (2010). Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9. International Journal of Oncology, 37, 337-345. https://doi.org/10.3892/ijo_00000682
MLA
Mühlen, S., Behren, A., Iftner, T., Simon, C."Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9". International Journal of Oncology 37.2 (2010): 337-345.
Chicago
Mühlen, S., Behren, A., Iftner, T., Simon, C."Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9". International Journal of Oncology 37, no. 2 (2010): 337-345. https://doi.org/10.3892/ijo_00000682