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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2010 Volume 37 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 37 Issue 2

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Article

Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation

  • Authors:
    • Masaki Shiota
    • Masatoshi Eto
    • Akira Yokomizo
    • Yasuhiro Tada
    • Ario Takeuchi
    • Momoe Itsumi
    • Katsunori Tatsugami
    • Takeshi Uchiumi
    • Seiji Naito

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8252, Japan
  • Pages: 509-517
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/ijo_00000700
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Abstract

Patients with advanced cancer including breast cancer, hepatocellular cancer and urothelial cancer frequently receive a chemotherapy regimen containing doxorubicin. However, doxorubicin-resistance is a major obstacle for cancer chemotherapy. Recently, several molecular-targeted agents have become available. Sorafenib (BAY 43-9006) is known to target multiple kinases and has demonstrated activity in renal cell and hepatocellular cancer. In this study, sorafenib was found to inhibit phosphorylation of the eukaryotic initiation factor-2α (eIF2α), induce cell cycle arrest at G2 phase and increase cellular apoptosis in doxorubicin-resistant human urothelial cell lines. An eIF2α kinase, PERK was responsible for eIF2α phosphorylation and PERK knockdown induced cellular apoptosis similar to sorafenib treatment in doxorubicin-resistant cancer cells. Furthermore, sorafenib sensitized doxorubicin-resistant cancer cells, but not their parental cells to oxidative stress exerted by both hydrogen peroxide and doxorubicin. In addition, PERK knockdown sensitized doxorubicin-resistant cancer cells to oxidative stress. In conclusion, PERK inhibition using sorafenib with or without doxorubicin might be a promising therapeutic approach for doxorubicin-resistant cancers retaining high phosphorylation levels of eIF2α.

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Copy and paste a formatted citation
Spandidos Publications style
Shiota M, Eto M, Yokomizo A, Tada Y, Takeuchi A, Itsumi M, Tatsugami K, Uchiumi T and Naito S: Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation. Int J Oncol 37: 509-517, 2010.
APA
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M. ... Naito, S. (2010). Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation. International Journal of Oncology, 37, 509-517. https://doi.org/10.3892/ijo_00000700
MLA
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M., Tatsugami, K., Uchiumi, T., Naito, S."Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation". International Journal of Oncology 37.2 (2010): 509-517.
Chicago
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M., Tatsugami, K., Uchiumi, T., Naito, S."Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation". International Journal of Oncology 37, no. 2 (2010): 509-517. https://doi.org/10.3892/ijo_00000700
Copy and paste a formatted citation
x
Spandidos Publications style
Shiota M, Eto M, Yokomizo A, Tada Y, Takeuchi A, Itsumi M, Tatsugami K, Uchiumi T and Naito S: Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation. Int J Oncol 37: 509-517, 2010.
APA
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M. ... Naito, S. (2010). Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation. International Journal of Oncology, 37, 509-517. https://doi.org/10.3892/ijo_00000700
MLA
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M., Tatsugami, K., Uchiumi, T., Naito, S."Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation". International Journal of Oncology 37.2 (2010): 509-517.
Chicago
Shiota, M., Eto, M., Yokomizo, A., Tada, Y., Takeuchi, A., Itsumi, M., Tatsugami, K., Uchiumi, T., Naito, S."Sensitivity of doxorubicin-resistant cells to sorafenib: Possible role for inhibition of eukaryotic initiation factor-2α phosphorylation". International Journal of Oncology 37, no. 2 (2010): 509-517. https://doi.org/10.3892/ijo_00000700
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