P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910

  • Authors:
    • Liang-Hui Li
    • Min-Hua Zheng
    • Qi Luo
    • Qing Ye
    • Bo Feng
    • Ai-Guo Lu
    • Ming-Liang Wang
    • Xue-Hua Chen
    • Li-Ping Su
    • Bing-Ya Liu
  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/ijo_00000746
  • Pages: 951-962
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pak1 has been reported to be overexpressed in colorectal cancer, but the role of Pak1 in colorectal cancer remains unclear. In this study, Pak1 expression and activity were associated with aggressive behavior of colorectal cancer. Overexpression of Pak1 increased colorectal cancer cell motility and invasion, whereas down-regulation of Pak1 expression or activity reduced colorectal cancer cell migration and invasion. In addition, activated Pak1 inhibited stress fiber and focal adhesion complex formation in colorectal cancer cells and led to formation of motile phenotypes. Importantly, activated Pak1 elicited phosphorylation of FAK at Ser-910 via an ERK-dependent pathway in colorectal cancer cell lines and clinical samples. In conclusion, our results suggest that activated Pak1 regulates colorectal cancer metastasis requiring an ERK-dependent phosphorylation of FAK at Ser-910.

Related Articles

Journal Cover

October 2010
Volume 37 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Zheng M, Luo Q, Ye Q, Feng B, Lu A, Wang M, Chen X, Su L, Liu B, Liu B, et al: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. Int J Oncol 37: 951-962, 2010
APA
Li, L., Zheng, M., Luo, Q., Ye, Q., Feng, B., Lu, A. ... Liu, B. (2010). P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. International Journal of Oncology, 37, 951-962. https://doi.org/10.3892/ijo_00000746
MLA
Li, L., Zheng, M., Luo, Q., Ye, Q., Feng, B., Lu, A., Wang, M., Chen, X., Su, L., Liu, B."P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910". International Journal of Oncology 37.4 (2010): 951-962.
Chicago
Li, L., Zheng, M., Luo, Q., Ye, Q., Feng, B., Lu, A., Wang, M., Chen, X., Su, L., Liu, B."P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910". International Journal of Oncology 37, no. 4 (2010): 951-962. https://doi.org/10.3892/ijo_00000746