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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2010 Volume 37 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2010 Volume 37 Issue 4

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Article

Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression

  • Authors:
    • Elena Pichichero
    • Rosella Cicconi
    • Maurizio Mattei
    • Marco Gallinella Muzi
    • Antonella Canini

  • View Affiliations / Copyright

    Affiliations: Department of Biology, Honey Research Center, University of Rome ‘Tor Vergata’, I-00133 Rome, Italy
  • Pages: 973-981
    |
    Published online on: October 1, 2010
       https://doi.org/10.3892/ijo_00000748
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Abstract

Honey has long been used in medicine for different purposes. Only recently, however, its antioxidant property and preventive effects against different diseases, such as cancer, have been highlighted. Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in acacia honey. It has previously been shown to be an anti-tumor agent. In this study, we investigated the antiproliferative role of honey or chrysin on human (A375) and murine (B16-F1) melanoma cell lines. The results of the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and the trypan blue exclusion test showed that both the tested compounds were able to induce an antiproliferative effect on melanoma cells in a dose- and time-dependent manner. Flow cytometry analysis indicated that cytotoxicity induced by honey or chrysin was mediated by G0/G1 cell cycle arrest and induction of hyperploid progression. Our results suggest that the anti-proliferative effects of honey are due mainly to the presence of chrysin. Chrysin may therefore be considered a potential candidate for both cancer prevention and treatment. Further investigation is needed to validate the contribution of chrysin in tumor therapy in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Pichichero E, Cicconi R, Mattei M, Muzi MG and Canini A: Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol 37: 973-981, 2010.
APA
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M.G., & Canini, A. (2010). Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. International Journal of Oncology, 37, 973-981. https://doi.org/10.3892/ijo_00000748
MLA
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A."Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression". International Journal of Oncology 37.4 (2010): 973-981.
Chicago
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A."Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression". International Journal of Oncology 37, no. 4 (2010): 973-981. https://doi.org/10.3892/ijo_00000748
Copy and paste a formatted citation
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Spandidos Publications style
Pichichero E, Cicconi R, Mattei M, Muzi MG and Canini A: Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol 37: 973-981, 2010.
APA
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M.G., & Canini, A. (2010). Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. International Journal of Oncology, 37, 973-981. https://doi.org/10.3892/ijo_00000748
MLA
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A."Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression". International Journal of Oncology 37.4 (2010): 973-981.
Chicago
Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A."Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression". International Journal of Oncology 37, no. 4 (2010): 973-981. https://doi.org/10.3892/ijo_00000748
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