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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2010 Volume 37 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2010 Volume 37 Issue 5

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Review Open Access

Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)

  • Authors:
    • Leonie Smeenk
    • Marion Lohrum
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
  • Pages: 1061-1070
    |
    Published online on: November 1, 2010
       https://doi.org/10.3892/ijo_00000757
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Abstract

The p53 protein is a tumor suppressor that plays a crucial role in cellular growth regulation inducing a plethora of response pathways. p53 post-translational modifications, p53-binding proteins, co-factors and the p53-family members p63 and p73 have all been described to contribute to p53 target gene regulation and hence cellular outcome. However, the molecular mechanisms that discriminate between the different p53-responses towards stress treatments have remained largely elusive. This review focuses on the topic of the molecular mechanisms behind target gene selectivity of the transcription factor p53 and provides insight into the latest era of p53 research.

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Copy and paste a formatted citation
Spandidos Publications style
Smeenk L and Lohrum M: Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). Int J Oncol 37: 1061-1070, 2010.
APA
Smeenk, L., & Lohrum, M. (2010). Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). International Journal of Oncology, 37, 1061-1070. https://doi.org/10.3892/ijo_00000757
MLA
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37.5 (2010): 1061-1070.
Chicago
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37, no. 5 (2010): 1061-1070. https://doi.org/10.3892/ijo_00000757
Copy and paste a formatted citation
x
Spandidos Publications style
Smeenk L and Lohrum M: Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). Int J Oncol 37: 1061-1070, 2010.
APA
Smeenk, L., & Lohrum, M. (2010). Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). International Journal of Oncology, 37, 1061-1070. https://doi.org/10.3892/ijo_00000757
MLA
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37.5 (2010): 1061-1070.
Chicago
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37, no. 5 (2010): 1061-1070. https://doi.org/10.3892/ijo_00000757
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