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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2010 Volume 37 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2010 Volume 37 Issue 5

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Article

Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry

  • Authors:
    • Tomonori Kaneko
    • Hajime Okita
    • Hideki Nakajima
    • Kazutoshi Iijima
    • Nao Ogasawara
    • Yoshitaka Miyagawa
    • Yohko U. Katagiri
    • Atsuko Nakagawa
    • Nobutaka Kiyokawa
    • Toshinori Sato
    • Junichiro Fujimoto

  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo 157-8535, Japan
  • Pages: 1279-1288
    |
    Published online on: November 1, 2010
       https://doi.org/10.3892/ijo_00000779
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Abstract

It is hoped that the gangliosides contained in neuroblastomas (NBs) can be used as outcome predictors. We used liquid chromatography-tandem mass spectrometry (LC-MS) to analyze the gangliosides expressed in 11 NB cell lines. LC-MS analysis detected a number of gangliosides, including acetylated forms, with significantly higher sensitivity than conventional high-performance thin-layer chromatography analysis, and the results revealed that the expression profiles of the gangliosides GD1a, GD2, and acetylated GD2 differed according to the NB cell line. Hierarchical clustering based on the ganglioside expression profiles obtained by LC-MS analysis revealed that the NB cell lines could be classified into three types according to their expression of these three gangliosides: A-type characterized by high expression of GD1a and low or no expression of GD2/acetylated GD2, B-type characterized by low or no expression of GD1a and high expression of GD2/acetylated GD2, and AB-type characterized by expression of both GD1a and GD2/acetylated GD2. Interestingly, all three MYCN non-amplified cell lines were classified into the A-type. The classification was found to be correlated with mRNA expression of ganglioside synthase and neural-differentiation-related genes. The results of this study indicate that LC-MS analysis is useful as a tool for glycosphingolipid research on malignancies.

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Copy and paste a formatted citation
Spandidos Publications style
Kaneko T, Okita H, Nakajima H, Iijima K, Ogasawara N, Miyagawa Y, Katagiri YU, Nakagawa A, Kiyokawa N, Sato T, Sato T, et al: Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry. Int J Oncol 37: 1279-1288, 2010.
APA
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y. ... Fujimoto, J. (2010). Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry. International Journal of Oncology, 37, 1279-1288. https://doi.org/10.3892/ijo_00000779
MLA
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y., Katagiri, Y. U., Nakagawa, A., Kiyokawa, N., Sato, T., Fujimoto, J."Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry". International Journal of Oncology 37.5 (2010): 1279-1288.
Chicago
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y., Katagiri, Y. U., Nakagawa, A., Kiyokawa, N., Sato, T., Fujimoto, J."Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry". International Journal of Oncology 37, no. 5 (2010): 1279-1288. https://doi.org/10.3892/ijo_00000779
Copy and paste a formatted citation
x
Spandidos Publications style
Kaneko T, Okita H, Nakajima H, Iijima K, Ogasawara N, Miyagawa Y, Katagiri YU, Nakagawa A, Kiyokawa N, Sato T, Sato T, et al: Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry. Int J Oncol 37: 1279-1288, 2010.
APA
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y. ... Fujimoto, J. (2010). Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry. International Journal of Oncology, 37, 1279-1288. https://doi.org/10.3892/ijo_00000779
MLA
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y., Katagiri, Y. U., Nakagawa, A., Kiyokawa, N., Sato, T., Fujimoto, J."Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry". International Journal of Oncology 37.5 (2010): 1279-1288.
Chicago
Kaneko, T., Okita, H., Nakajima, H., Iijima, K., Ogasawara, N., Miyagawa, Y., Katagiri, Y. U., Nakagawa, A., Kiyokawa, N., Sato, T., Fujimoto, J."Neuroblastoma cells can be classified according to glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry". International Journal of Oncology 37, no. 5 (2010): 1279-1288. https://doi.org/10.3892/ijo_00000779
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