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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2010 Volume 37 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2010 Volume 37 Issue 5

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Article

Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model

  • Authors:
    • Ryoji Eguchi
    • Yoshihiro Fujimori
    • Toshiro Ohta
    • Kazuhiro Kunimasa
    • Takashi Nakano

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
  • Pages: 1289-1296
    |
    Published online on: November 1, 2010
       https://doi.org/10.3892/ijo_00000780
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Abstract

To study endothelial injury in vitro, we established a three-dimensional (3-D) blood vessel model in which human umbilical vein endothelial cells were grown in the presence of basic fibroblast growth factor and vascular endothelial growth factor. We then performed comparative studies on cisplatin (cis-platinum-diammine-dichloride, CDDP)-induced endothelial injury in 3-D and monolayer cultures. In 3-D culture, CDDP induced cell death and tube breakdown without DNA damage, whereas CDDP induced apoptosis accompanied by DNA damage in monolayer culture. CDDP also induced caspase-3 activation in a concentration-dependent manner in both cultures. A broad-spectrum caspase inhibitor, zVAD-fmk, failed to prevent CDDP-induced cell death and tube breakdown in 3-D culture, whereas zVAD-fmk suppressed CDDP-induced apoptosis in monolayer culture. A calpain inhibitor, MDL28170, attenuated CDDP-induced cell death and tube breakdown in 3-D culture, but not apoptosis in monolayer culture. These results showed that calpain is involved in CDDP-induced endothelial injury in 3-D culture and there are significant differences in signaling pathways between 3-D and monolayer cultures.

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Copy and paste a formatted citation
Spandidos Publications style
Eguchi R, Fujimori Y, Ohta T, Kunimasa K and Nakano T: Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model. Int J Oncol 37: 1289-1296, 2010.
APA
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., & Nakano, T. (2010). Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model. International Journal of Oncology, 37, 1289-1296. https://doi.org/10.3892/ijo_00000780
MLA
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., Nakano, T."Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model". International Journal of Oncology 37.5 (2010): 1289-1296.
Chicago
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., Nakano, T."Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model". International Journal of Oncology 37, no. 5 (2010): 1289-1296. https://doi.org/10.3892/ijo_00000780
Copy and paste a formatted citation
x
Spandidos Publications style
Eguchi R, Fujimori Y, Ohta T, Kunimasa K and Nakano T: Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model. Int J Oncol 37: 1289-1296, 2010.
APA
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., & Nakano, T. (2010). Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model. International Journal of Oncology, 37, 1289-1296. https://doi.org/10.3892/ijo_00000780
MLA
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., Nakano, T."Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model". International Journal of Oncology 37.5 (2010): 1289-1296.
Chicago
Eguchi, R., Fujimori, Y., Ohta, T., Kunimasa, K., Nakano, T."Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model". International Journal of Oncology 37, no. 5 (2010): 1289-1296. https://doi.org/10.3892/ijo_00000780
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